We investigate mesoscopic fluctuations in the spin polarization generated by a static electric field and by Rashba spin-orbit interaction in a disordered 2D electron gas. In a diagrammatic approach we find that the out-of-plane polarization -- while being zero for self-averaging systems -- exhibits large sample-to-sample fluctuations which are shown to be well within experimental reach. We evaluate the disorder-averaged variance of the susceptibility and find its dependence on magnetic field, spin-orbit interaction, dephasing, and chemical potential difference.
