全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Prevalence and Antibiotic Resistance Pattern of Escherichia coli and Klebsiella pneumoniae in Urine Tract Infections at the La Paz Medical Center, Malabo, Equatorial Guinea

DOI: 10.4236/ojmm.2015.54022, PP. 177-183

Keywords: Urine Tract Infections, Antibiotic Resistance, Klebsiella pneumonia, Escherichia coli

Full-Text   Cite this paper   Add to My Lib

Abstract:

The study was conducted to isolate and determine the antibiotic resistance in Escherichia coli and Klebsiella pneumonia from urine samples over a 2-year period (August 2013-September 2015) at the La Paz Medical Center, Malabo. A retrospective analysis of 785 urine culture samples over a 2-year period August 2013-September 2015 was carried out according to the routine protocol of urinalysis. Bacterial etiological agents were isolated from 155 (19.7%) samples with highest prevalence of Escherichia coli (55.5%) followed by Klebsiella pneumonia (23.2%), Proteus mirabilis (4.5%), Pseudomonas species (3.2%), Enterobacter species (2.6%), Enterococcus faecalis (2.6%) and others species (8.4%). The E. coli and K. pneumonia represent 78.7% of all isolated bacterial strains. The E. coli and K. pneumoniae isolates possess highly resistant to ampicillin, Trimethoprim/Sulfamethoxazole, Doxycycline, Amoxicicline/Clavulanic acid. Whereas K. pneumonia demonstrated also to be highly resistant to Gentamycin, Cefuroxime and Ceftriaxon, low level of resistance to Piperacilin/Tazobactam, Amikacin and the lowest to Imipenem. The alarming level of MDR strains to the first choice antibiotics treatment was observed.

References

[1]  Tansarli, G., Athanasiou, S. and Falagas, M. (2013) Evaluation of Antimicrobial Susceptibility of Enterobacteriaceae Causing Urinary Tract Infections in Africa. Antimicrobial Agents and Chemotherapy, 57, 3628-3639.
http://dx.doi.org/10.1128/AAC.00359-13
[2]  WHO (2014) Antimicrobial Resistance: Global Report on Surveillance.
http://www.who.int/drugresistance/documents/surveillancereport/en/
[3]  Schito, G., Naber, K., Botto, H., et al. (2009) The ARESC Study: An International Survey on the Antimicrobial Resistance of Pathogens Involved in Uncomplicated Urinary Tract Infections. International Journal of Antimicrobial Agents, 34, 407-413.
http://dx.doi.org/10.1016/j.ijantimicag.2009.04.012
[4]  Foxman, B. (2010) The Epidemiology of Urinary Tract Infection. Nature Reviews Urology, 7, 653-660.
http://dx.doi.org/10.1038/nrurol.2010.190
[5]  Habte, T., Dube, S., Ismail, N. and Hoosen, A. (2009) Hospital and Community Isolates of Uropathogens at a Tertiary Hospital in South Africa. South African Medical Journal, 99, 584-587.
[6]  El Bouamri, M., Arsalane, L., El Kamouni, Y. and Zouhair, S. (2015) Antimicrobial Susceptibility of Urinary K. pneumonia and the Emergence of Carbapenem-Resistance Strain. African Journal of Urology, 21, 36-40.
http://dx.doi.org/10.1016/j.afju.2014.10.004
[7]  Abejew, A., Denboba, A. and Mekonnen, A. (2014) Prevalence and Antibiotic Resistance Pattern of Urinary Tract Bacterial Infections in Dessie Area, North-East Ethiopia. BMC Reseach Notes, 7, 687.
http://dx.doi.org/10.1186/1756-0500-7-687
[8]  Hima-Lerible, H., Menard, D. and Talarmin, A. (2003) Antimicrobial Resistance among Uropathogenes That Cause Community-Acquired Urinary Tract Infection in Bangui, Central African Republic. Journal of Antimicrobial Chemotherapy, 51, 192-194.
http://dx.doi.org/10.1093/jac/dkg053
[9]  Randrianirina, F., Soares, J., Carod, J., et al. (2007) Antimicrobial Resistance among Uropathgens That Cause Community-Acquired Urinary Tract Infections in Antananario, Madagascar. Journal of Antimicrobial Chemotherapy, 59, 309.
http://dx.doi.org/10.1093/jac/dkl466
[10]  Moroh, J., Fleury, Y., Tia, H., et al. (2015) Diversity and Antibiotic Resistance of Urapathogenic Bacteria from Abijan. African Journal of Urology, 20, 18-24.
http://dx.doi.org/10.1016/j.afju.2013.11.005
[11]  Iregbu, K. and Princewill, P. (2013) Urinary Tract Infection in a Tertiary Hospital in Abuja, Nigeria. African Journal of Clinical and Experimental Microbiology, 14, 167-173.
http://dx.doi.org/10.4314/ajcem.v14i3.9
[12]  Rerambiah, L., Ndong, J., Massoua, P., et al. (2014) Antimicrobial Profiles of Bacterial Clinical Isolates from the Gabonese National Laboratory of Public Health: Data from Routine Activity. International Journal of Infectious Diseases, 29, 48-53.
http://dx.doi.org/10.1016/j.ijid.2014.01.015
[13]  Mbaga, J., Dube, S. and Munyanduki, H. (2010) Prevalence and Drug Resistance in Bacteria of the Urinary Tract Infections in Bulawayo Province, Zimbabwe. East African Journal of Public Health, 7, 229-232.
[14]  Akoachere, J., Yvone, S., Akum, N. and Seraphine, E. (2012) Etiologic Profile and Antimicrobial Susceptibility of Community-Acquired Urinary Tract Infection in Two Cameroonian Towns. BMC Research Notes, 5, 219.
http://dx.doi.org/10.1186/1756-0500-5-219
[15]  Ngwai, Y., Akpotu, M., Okidake, R., et al. (2011) Antimicrobial Susceptibility of Escherichia coli and Other Coliforms Isolated from Urine of Asymptomatic Students in Bayelsa State, Nigeria. African Journal of Microbiology Research, 5, 184-191.
[16]  Clinical Laboratory Standards Institute (2012) Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Eleventh Edition. M02-A11, Volume 32.
[17]  Clinical Laboratory Standards Institute (2013) Performance Standards for Antimicrobial Susceptibility Testing. M100-S23, Volume 33.
[18]  Clinical Laboratory Standards Institute (2014) Performance Standards for Antimicrobial Susceptibility Testing. M100-S24, Volume 34.
[19]  http://www.cdc.gov/hicpac/pdf/guidelines/MDROGuideline2006.pdf
[20]  Magiorakos, A., Srinivasan, A., Carey, R., et al. (2012) Multidrug-Resistant, Extensively Drug-Resistant and Pandrug-Resistant Bacteria: An International Expert Proposal for Interim Standard Definitions for Acquired Resistance. Clinical Microbiology and Infection, 18, 268-281.
http://dx.doi.org/10.1111/j.1469-0691.2011.03570.x
[21]  Ibrahim, M., Bilal, N. and Hamid, M. (2012) Increased Multi Drug Resistant Eschrichia coli from Hospitals in Khartoum State, Sudan. African Health Sciences, 12, 368-375.
[22]  Obirikorang, C., Quaye, L., Bio, F., et al. (2012) Asyptomatic Bacteriuria among Pregnan Women Attending Antenatal Clinic at the University Hospital, Kumasi, Ghana. Journal of Medicine and Biomedical Sciences, 1, 38-44.
[23]  Eshetie, S., Unakalet, C., Gelaw, A., et al. (2015) Multidrug Resistant and Carbapenemase Producing Enterobacteriaceae among Patients with Urinary Tract Infection at Referral Hospital, Northwest Ethiopia. Antimicrobial Resistance and Infection Control, 4, 12.
http://dx.doi.org/10.1186/s13756-015-0054-7

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133