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PeerJ  2015 

The selenium content of SEPP1 versus selenium requirements in vertebrates

DOI: 10.7287/peerj.preprints.784v1

Keywords: Selenoprotein P,Selenium requirements,Nutrition,SEPP1

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Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. The Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we provide evidence that vertebrate SEPP1 Sec content correlates positively with Se requirements (R2=0.88). As the Se content of full length SEPP1 is genetically determined, this presents a unique case where a nutrient requirement can be predicted based on genomic sequence information.


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