噪声性耳聋(noise-induced hearing loss, NIHL)是世界上最流行的职业病之一，其发病机制十分复杂，至今仍不清楚。随着研究技术的快速发展，人们开始试图从分子角度来理解疾病，该文就近几年对于噪声性耳聋易感基因研究的进展作一综述。 Noise-induced hearing loss (NIHL) is one of the most popular professional diseases across countries. The specific pathogenesis of NIHL is complicated and remains unclear. Now researchers try to understand NIHL with advanced molecular biological technology, which dives deep into gene level. This review will try to find out what researchers have found through years of re- searches.
Fortunato, G., Marciano, E., Zarrilli, F., Mazzaccara, C., Intrieri, M., Calcagno, G., Vitale, D.F., La Manna, P., Saulino, C., Marcelli, V. and Sacchetti, L. (2004) Paraoxonase and superoxide dismutasegene polymorphisms and noise-in- duced hearing loss. Clinical Chemistry, 50, 2012-2018.
Konings, A.,Van Laer, L., Pawelczyk, M., Carlsson, P.I., Bondeson, M.L., Rajkowska, E., Dudarewicz, A., Vandevelde, A., Fransen, E., Huyghe, J., Borg, E., Sliwinska-Kowalska, M. and Van Camp, G. (2007) Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. Human Molecular Genetics, 16, 1872-1883.
Liu, Y.M., Li, X.D., Guo, X., Liu, B., Lin, A.H., Ding, Y.L. and Rao, S.Q. (2010) SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Disease Markers, 28, 137- 147.
Van Laer, L., Carlsson, P.I., Ottschytsch, N., Bondeson, M.L., Konings, A., Vandevelde, A., Dieltjens, N., Fransen, E., Snyders, D., Borg, E., Raes, A. and Van Camp, G. (2006) The contribution of genes involved in potassium recycling in the inner ear to noise-induced hearing loss. Human Mutation, 27, 786-795.
Yang, M., Tan, H., Yang, Q., Wang, F., Yao, H., Wei, Q., Tanguay, R.M. and Wu, T. (2006) Associa-tion of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell Stress and Chaperones, 11, 233-239.
Konings, A., Van Laer, L., Michel, S., Pawelczyk, M., Carlsson, P.I., Bondeson, M.L., Rajkowska, E., Dudarewicz, A., Vandevelde, A., Fransen, E., Huyghe, J., Borg, E., Sliwinska-Kowalska, M. and Van Camp, G. (2009) Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. European Journal of Human Genetics, 17, 329-335.