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蛋白去乙酰基酶SIRT1的免疫调节效应及机制
Immunomodulation and Mechanism of Protein Deacetylase SIRT1

DOI: 10.12677/IS.2013.12002, PP. 7-10

Keywords: SIRT1;巨噬细胞;T细胞;免疫调节
SIRT1
, Macrophages, T Cells, Immune Modulation

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Abstract:

机体免疫分为天然免疫和适应性免疫,分别由不同的免疫细胞介导。SIRT1 (silent mating type information regulation 2 homolog 1)是一种具有烟酰胺腺嘌呤二核苷酸(Nicotinamide Adenine Dinucleotide, NAD)依赖性的蛋白去乙酰基酶活性的转录调节因子,在细胞寿命和机体代谢中发挥重要作用。近年来,SIRT1在免疫中的调控作用逐渐为研究者所重视。本文仅就SIRT1在天然免疫和适应性免疫中的调控效应及分子机制做一简要综述。
Different kinds of lymphocytes could be involved in the innate immunity and adaptive immunity. Silent mating type information regulation 2 homolog 1 (SIRT1) is a Nicotinamide Adenine Dinucleotide (NAD)-dependent protein deacetylase, which plays a critical role in life span and metabolism. Recently, the immune functional studies of SIRT1 have become a hot spot in immunological field. This review only summarizes the modulation of SIRT1 on both innate immunity and adaptive immunity and its molecular mechanism.

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