All Title Author
Keywords Abstract


Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing β-Chitosan Weak Acid Salt

DOI: 10.4236/pp.2014.54042, PP. 349-355

Keywords: β-Chitosan, Bile Acid Adsorption, Alginate Gel Bead, Hyperlipidemia

Full-Text   Cite this paper   Add to My Lib

Abstract:

Recently, potential applications for β-chitosan (β-CS) have been examined. In the present study, calcium-induced alginate gel beads (Alg-Ca) containing weak acid salts of β-CS were prepared and examined with regard to their ability to adsorb bile acids in vitro. More than 70% of taurocholate dissolved in solution was taken up by Alg-Ca containing 100 mg β-CS, sim. ilar to the degree of uptake observed with Alg-Ca containing α-CS salt. The adsorption of bile acid was affected by the absolute amount of β-CS and/or the acid concentration of the preparation. A secondary bile acid, taurodeoxycholate, was also adsorbed by Alg-Ca containing weak acid salts of β-CS. Therefore, β-CS might be used to adsorb bile acids within the gastrointestinal tract in the same manner as an anion-exchange resin, and thus serve as a complementary means by which to prevent hyperlipidemia.

References

[1]  Fan, Y., Saito, T. and Isogai, A. (2008) Preparation of Chitin Nanofibers from Squid Pen β-Chitin by Simple Mechanical Treatment under Acid Conditions. Biomacromolecules, 9, 1919-1923. http://dx.doi.org/10.1021/bm800178b
[2]  Jung, J. and Zhao, Y. (2013) Impact of the Structural Differences between α- and β-Chitosan on Their Depolymerizing Reaction and Antibacterial Activity. Journal of Agricultural Food Chemistry, 61, 8783-8789.http://dx.doi.org/10.1021/jf4018965
[3]  Subhapradha, N., Ramasamy, P., Shanmugam, V., Madeswaran, P., Srinivasan, A. and Shanmugam, A. (2013) Physicochemical Characterization of β-Chitosan from Sepioteuthis Lessoniana Gladius. Food Chemistry, 141, 907-913.http://dx.doi.org/10.1016/j.foodchem.2013.03.098
[4]  Hu, L., Sun, Y. and Wu, Y. (2013) Advances in Chitosan-Based Drug Delivery Vehicles. Nanoscale, 5, 3103-3111.http://dx.doi.org/10.1039/c3nr00338h
[5]  Shukla, S.K., Mishra, A.K., Arotiba, O.A. and Mamba, B.B. (2013) Chitosan-Based Nanomaterials: A State-of-the-Art Review. International Journal of Biological Macromolecules, 59, 46-58. http://dx.doi.org/10.1016/j.ijbiomac.2013.04.043
[6]  Ragelle, H., Vandermeulen, G. and Preat, V. (2013) Chitosan-Based siRNA Delivery Systems. Journal of Controlled Release, 172, 207-218. http://dx.doi.org/10.1016/j.jconrel.2013.08.005
[7]  Pahwa, R., Saini, N., Kumar, V. and Kohli, K. (2012) Chitosan-Based Gastroretentive Floating Drug Delivery Technology: An Update Review. Expert Opinion on Drug Delivery, 9, 525-539. http://dx.doi.org/10.1517/17425247.2012.673581
[8]  Zhang, J., Liu, J., Li, L. and Xia, W. (2008) Dietary Chitosan Improves Hypercholesterolemia in Rats Fed High-Fat Diets. Nutrition Research, 28, 383-390. http://dx.doi.org/10.1016/j.nutres.2007.12.013
[9]  Liu, S.H., He, S.P. and Chiang, M.T. (2012) Effect of Long-Term Feeding of Chitosan on Postprandial Lipid Responses and Lipid Metabolism in a High-Sucrose-Diet-Impaired Glucose-Tolerant Rat Model. Journal of Agricultural Food Chemistry, 60, 4306-4313. http://dx.doi.org/10.1021/jf300792b
[10]  Murata, Y., Kojima, N. and Kawashima, S. (2003) Function of a Chitosan-Orotic Acid Salt in the Gastrointestinal Tract. Biological & Pharmaceutical Bulletin, 26, 687-690. http://dx.doi.org/10.1248/bpb.26.687
[11]  Murata, Y., Nagaki, K., Kofuji, K., Sanae, F., Kontani, H. and Kawashima, S. (2006) Adsorption of Bile Acid by Chitosan Salts Prepared with Cinnamic Acid and Analogue Compounds. Journal of Biomaterials Science, Polymer Edition, 17, 781-789. http://dx.doi.org/10.1163/156856206777656517
[12]  Murata, Y., Nagaki, K., Kofuji, K. and Kishi, T. (2010) Functions of Chitosan-Ferulic Acid Salt for Prevention of Hypertension. Food Science and Technology Research, 16, 437-442. http://dx.doi.org/10.3136/fstr.16.437
[13]  Rosmilah, M., Shahnaz, M., Zailatul, H.M., Noormalin, A. and Normilah, I. (2012) Identification of Tropomyosin and Arginine Kinase as Major Allergens of Portunus pelagicus (Blue Swimming Crab). Tropical Biomedicine, 29, 467-478.
[14]  Misnan, R., Murad, S., Yadzir, Z.H. and Abdullah, N. (2012) Identification of the Major Allergens of Charybdis feriatus (Red Crab) and Its Cross-Reactivity with Portunus pelagicus (Blue Crab). Asian Pacific Journal of Allergy and Immunology, 30, 285-293.
[15]  Bae, M.-J., Shin, H.S., Kim, E.-K., Kim, J. and Shon, D.-H. (2013) Oral Administration of Chitin and Chitosan Prevents Peanut-Induced Anaphylaxis in a Murine Food Allergy Model. International Journal of Biological Macromolecules, 61, 164-168. http://dx.doi.org/10.1016/j.ijbiomac.2013.06.017
[16]  Jung, J., Cavender, G. and Zhao, Y. (2014) The Contribution of Acidulant to the Antibacterial Activity of Acid Soluble α- and β-Chitosan Solutions and Their Films. Applied Microbiology and Biotechnology, 98, 425-435.http://dx.doi.org/10.1007/s00253-013-5334-7
[17]  Martin, C.C. (1982) The Liver, Biology and Pathobiology. Arias, A., Ed., Raven Press, New York.

Full-Text

comments powered by Disqus