All Title Author
Keywords Abstract

Viruses  2013 

Phylogeographic Diversity of Pathogenic and Non-Pathogenic Hantaviruses in Slovenia

DOI: 10.3390/v5123071

Keywords: hantavirus, Slovenia, epidemiology, genetic diversity, phylogeography

Full-Text   Cite this paper   Add to My Lib

Abstract:

Slovenia is a very diverse country from a natural geography point of view, with many different habitats within a relatively small area, in addition to major geological and climatic differences. It is therefore not surprising that several small mammal species have been confirmed to harbour hantaviruses: A. flavicollis (Dobrava virus), A. agrarius (Dobrava virus–Kurkino), M. glareolus (Puumala virus), S. areanus (Seewis virus), M. agrestis, M. arvalis and M. subterraneus (Tula virus). Three of the viruses, namely the Dobrava, Dobrava–Kurkino and Puumala viruses, cause disease in humans, with significant differences in the severity of symptoms. Due to changes in haemorrhagic fever with renal syndrome cases (HFRS) epidemiology, a detailed study on phylogenetic diversity and molecular epidemiology of pathogenic and non-pathogenic hantaviruses circulating in ecologically diverse endemic regions was performed. The study presents one of the largest collections of hantavirus L, M and S sequences obtained from hosts and patients within a single country. Several genetic lineages were determined for each hantavirus species, with higher diversity among non-pathogenic compared to pathogenic viruses. For pathogenic hantaviruses, a significant geographic clustering of human- and rodent-derived sequences was confirmed. Several geographic and ecological factors were recognized as influencing and limiting the formation of endemic areas.

References

[1]  Radosevic, Z.; Mohacek, I. The problem of nephropathia epidemica Myhrman-Zetterholm in relation to acute interstitial nephritis. Acta Med. Scand. 1954, 149, 221–228, doi:10.1111/j.0954-6820.1954.tb11429.x.
[2]  Avsic-Zupanc, T.; Xiao, S.Y.; Stojanovic, R.; Gligic, A.; van der Groen, G.; LeDuc, J.W. Characterization of dobrava virus: A hantavirus from Slovenia, Yugoslavia. J. Med. Virol. 1992, 38, 132–137, doi:10.1002/jmv.1890380211.
[3]  Avsic-Zupanc, T.; Petrovec, M.; Furlan, P.; Kaps, R.; Elgh, F.; Lundkvist, A. Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia--a 10-year survey. Clin. Infect. Dis. 1999, 28, 860–865.
[4]  Avsic-Zupanc, T.; Nemirov, K.; Petrovec, M.; Trilar, T.; Poljak, M.; Vaheri, A.; Plyusnin, A. Genetic analysis of wild-type Dobrava hantavirus in Slovenia: Co-existence of two distinct genetic lineages within the same natural focus. J. Gen. Virol. 2000, 81, 1747–1755.
[5]  Avsic-Zupanc, T.; Petrovec, M.; Duh, D.; Plyusnina, A.; Lundkvist, A.; Plyusnin, A. Puumala hantavirus in Slovenia: Analyses of S and M segment sequences recovered from patients and rodents. Virus Res. 2007, 123, 204–210.
[6]  Korva, M.; Duh, D.; Puterle, A.; Trilar, T.; Zupanc, T.A. First molecular evidence of Tula hantavirus in Microtus voles in Slovenia. Virus Res. 2009, 144, 318–322, doi:10.1016/j.virusres.2009.04.021.
[7]  Resman, K.; Korva, M.; Fajs, L.; Zidaric, T.; Trilar, T.; Zupanc, T.A. Molecular evidence and high genetic diversity of shrew-borne Seewis virus in Slovenia. Virus Res. 2013, 177, 113–117.
[8]  Mr?i?, N. Biotska raznovrstnost v Sloveniji: Slovenija – ?vro?a to?ka? Evrope; Ministrstvo za okolje in prostor, Uprava RS za varstvo narave: Ljubljana, Slovenia, 1997; p. 129.
[9]  Klempa, B.; Fichet-Calvet, E.; Lecompte, E.; Auste, B.; Aniskin, V.; Meisel, H.; Denys, C.; Koivogui, L.; ter Meulen, J.; Kruger, D.H. Hantavirus in African wood mouse, Guinea. Emerg. Infect. Dis. 2006, 12, 838–840.
[10]  Papa, A.; Johnson, A.M.; Stockton, P.C.; Bowen, M.D.; Spiropoulou, C.F.; Alexiou-Daniel, S.; Ksiazek, T.G.; Nichol, S.T.; Antoniadis, A. Retrospective serological and genetic study of the distribution of hantaviruses in Greece. J. Med. Virol. 1998, 55, 321–327, doi:10.1002/(SICI)1096-9071(199808)55:4<321::AID-JMV11>3.0.CO;2-H.
[11]  Chu, Y.K.; Jennings, G.B.; Schmaljohn, C.S. A vaccinia virus-vectored Hantaan virus vaccine protects hamsters from challenge with Hantaan and Seoul viruses but not Puumala virus. J. Virol. 1995, 69, 6417–6423.
[12]  Bowen, M.D.; Gelbmann, W.; Ksiazek, T.G.; Nichol, S.T.; Nowotny, N. Puumala virus and two genetic variants of Tula virus are present in Austrian rodents. J. Med. Virol. 1997, 53, 174–181, doi:10.1002/(SICI)1096-9071(199710)53:2<174::AID-JMV11>3.0.CO;2-J.
[13]  Schlegel, M.; Radosa, L.; Rosenfeld, U.M.; Schmidt, S.; Triebenbacher, C.; Lohr, P.W.; Fuchs, D.; Heroldova, M.; Janova, E.; Stanko, M.; et al. Broad geographical distribution and high genetic diversity of shrew-borne Seewis hantavirus in Central Europe. Virus Genes 2012, 45, 48–55.
[14]  Song, J.W.; Gu, S.H.; Bennett, S.N.; Arai, S.; Puorger, M.; Hilbe, M.; Yanagihara, R. Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus). Virol. J. 2007, 4, 114, doi:10.1186/1743-422X-4-114.
[15]  Tamura, K.; Peterson, D.; Peterson, N.; Stecher, G.; Nei, M.; Kumar, S. MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 2011, 28, 2731–2739, doi:10.1093/molbev/msr121.
[16]  Posada, D. jModelTest: Phylogenetic model averaging. Mol. Biol. Evol. 2008, 25, 1253–1256.
[17]  Huelsenbeck, J.P.; Ronquist, F. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 2001, 17, 754–755.
[18]  Drummond, A.J.; Rambaut, A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol. Biol. 2007, 7, 214.
[19]  Deli?, T.; Lu?trik, R.; Kljun, F.; Poto?nik, H. Species diversity and composition of small mammal communities in Goteni?ka gora (S Slovenia). Nat. Slov. 2012, 15, 13–26.
[20]  Kry?tufek, B. Sesalci Slovenije; Prirodoslovni muzej Slovenije: Ljubljana, Slovenia, 1991; pp. 150–159.
[21]  Smith, M.J.; White, A.; Lambin, X.; Sherratt, J.A.; Begon, M. Delayed density-dependent season length alone can lead to rodent population cycles. Am. Nat. 2006, 167, 695–704.
[22]  Scharninghausen, J.J.; Pfeffer, M.; Meyer, H.; Davis, D.S.; Honeycutt, R.L.; Faulde, M. Genetic evidence for Tula virus in Microtus arvalis and Microtus agrestis populations in Croatia. Vector Borne Zoonotic Dis. 2002, 2, 19–27.
[23]  Vapalahti, O.; Mustonen, J.; Lundkvist, A.; Henttonen, H.; Plyusnin, A.; Vaheri, A. Hantavirus infections in Europe. Lancet Infect. Dis. 2003, 3, 653–661.
[24]  Mills, J. Biodiversity loss and emerging infectious disease: An example from the rodent-borne hemorrhagic fevers. Biodiversity 2006, 7, 9–17, doi:10.1080/14888386.2006.9712789.
[25]  Suzán, G.; Marcé, E.; Giermakowski, J.T.; Armién, B.; Pascale, J.; Mills, J.; Ceballos, G.; Gómez, A.; Aguirre, A.A.; Salazar-Bravo, J.; et al. The effect of habitat fragmentation and species diversity loss on hantavirus prevalence in Panama. Ann. N. Y. Acad. Sci. 2008, 1149, 80–83.
[26]  Madhav, N.K.; Wagoner, K.D.; Douglass, R.J.; Mills, J.N. Delayed density-dependent prevalence of Sin Nombre virus antibody in Montana deer mice (Peromyscus maniculatus) and implications for human disease risk. Vector Borne Zoonotic Dis. 2007, 7, 353–364.
[27]  Linard, C.; Tersago, K.; Leirs, H.; Lambin, E.F. Environmental conditions and Puumala virus transmission in Belgium. Int. J. Health Geogr. 2007, 6, 55, doi:10.1186/1476-072X-6-55.
[28]  Heyman, P.; Thoma, B.R.; Marie, J.L.; Cochez, C.; Essbauer, S.S. In search for factors that drive hantavirus epidemics. Front. Physiol. 2012, 3, 237.
[29]  Linard, C.; Lamarque, P.; Heyman, P.; Ducoffre, G.; Luyasu, V.; Tersago, K.; Vanwambeke, S.O.; Lambin, E.F. Determinants of the geographic distribution of Puumala virus and Lyme borreliosis infections in Belgium. Int. J. Health Geogr. 2007, 6, 15, doi:10.1186/1476-072X-6-15.
[30]  Loehman, R.A.; Elias, J.; Douglass, R.J.; Kuenzi, A.J.; Mills, J.N.; Wagoner, K. Prediction of Peromyscus maniculatus (deer mouse) population dynamics in Montana, USA, using satellite-driven vegetation productivity and weather data. J. Wildl. Dis. 2012, 48, 348–360, doi:10.7589/0090-3558-48.2.348.
[31]  Reusken, C.; de Vries, A.; Adema, J.; Vos, W.; Joke van der, G.; Bekker, D.; Heyman, P. First genetic detection of Tula hantavirus in wild rodents in the Netherlands. J. Infect. 2008, 57, 500–503, doi:10.1016/j.jinf.2008.09.032.
[32]  Verhagen, R.; Leirs, H.; Tkachenko, E.; van der Groen, G. Ecological and epidemiological data on Hantavirus in bank vole populations in Belgium. Arch. Virol. 1986, 91, 193–205, doi:10.1007/BF01314280.
[33]  Goodin, D.G.; Koch, D.E.; Owen, R.D.; Chu, Y.K.; Hutchinson, J.M.S.; Jonsson, C.B. Land cover associated with hantavirus presence in Paraguay. Glob. Ecol. Biogeogr. 2006, 15, 519–527.
[34]  Pupila, A.; Bergmanis, U. Species diversity, abundance and dynamics of small mammals in Eastern Latvia. Acta Univ. Latv. 2006, 710, 93–101.

Full-Text

comments powered by Disqus