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Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial

DOI: 10.1155/2013/861893

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We report secondary findings from a randomized controlled trial on the effects of exercise on memory in older adults with probable MCI. We randomized 86 women aged 70–80 years with subjective memory complaints into one of three groups: resistance training, aerobic training, or balance and tone (control). All participants exercised twice per week for six months. We measured verbal memory and learning using the Rey Auditory Verbal Learning Test (RAVLT) and spatial memory using a computerized test, before and after trial completion. We found that the aerobic training group remembered significantly more items in the loss after interference condition of the RAVLT compared with the control group after six months of training. In addition, both experimental groups showed improved spatial memory performance in the most difficult condition where they were required to memorize the spatial location of three items, compared with the control group. Lastly, we found a significant correlation between spatial memory performance and overall physical capacity after intervention in the aerobic training group. Taken together, our results provide support for the prevailing notion that exercise can positively impact cognitive functioning and may represent an effective strategy to improve memory in those who have begun to experience cognitive decline. 1. Introduction Cognitive decline is one of the most pressing health care issues of the 21st century. Currently worldwide, one new case of dementia is detected every seven seconds [1] and the number of people affected is projected to be over 80 million by 2040 [1]. Thus, the societal value of developing effective intervention strategies cannot be overstated [2]. To date, pharmacological interventions for dementia have remained medically challenging at best. As a result, there has been growing interest in exercise training as an alternative intervention strategy. The primary aim of our current study was to investigate the efficacy of exercise as an intervention strategy to improve memory performance in older adults who have already begun to experience cognitive decline—namely, those with mild cognitive impairment (MCI). MCI is characterized by cognitive decline that is greater than expected for an individual’s age and education level, but does not significantly interfere with everyday function (i.e., instrumental activities of daily living) [3]. Importantly, MCI is a well-recognized risk factor for dementia; longitudinal studies report that seniors with MCI develop Alzheimer’s disease at a rate of 10–30% annually [4, 5], compared

References

[1]  C. P. Ferri, M. Prince, C. Brayne et al., “Global prevalence of dementia: a Delphi consensus study,” The Lancet, vol. 366, no. 9503, pp. 2112–2117, 2005.
[2]  R. Brookmeyer, E. Johnson, K. Ziegler-Graham, and H. M. Arrighi, “Forecasting the global burden of Alzheimer's disease,” Alzheimer's and Dementia, vol. 3, no. 3, pp. 186–191, 2007.
[3]  R. C. Petersen, R. Doody, A. Kurz et al., “Current concepts in mild cognitive impairment,” Archives of Neurology, vol. 58, no. 12, pp. 1985–1992, 2001.
[4]  A. Busse, J. Bischkopf, S. G. Riedel-Heller, and M. C. Angermeyer, “Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria. Results of the Leipzig Longitudinal Study of the Aged (LEILA75+),” British Journal of Psychiatry, vol. 182, pp. 449–454, 2003.
[5]  R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, and E. Kokmen, “Mild cognitive impairment: clinical characterization and outcome,” Archives of Neurology, vol. 56, no. 3, pp. 303–308, 1999.
[6]  T. Liu-Ambrose, L. S. Nagamatsu, P. Graf, B. L. Beattie, M. C. Ashe, and T. C. Handy, “Resistance training and executive functions: a 12-month randomized controlled trial,” Archives of Internal Medicine, vol. 170, no. 2, pp. 170–178, 2010.
[7]  T. Liu-Ambrose, L. S. Nagamatsu, M. W. Voss, K. M. Khan, and T. C. Handy, “Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial,” Neurobiology of Aging, vol. 33, no. 8, pp. 1690–1698, 2011.
[8]  S. J. Colcombe, A. F. Kramer, K. I. Erickson et al., “Cardiovascular fitness, cortical plasticity, and aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 9, pp. 3316–3321, 2004.
[9]  N. T. Lautenschlager, K. L. Cox, L. Flicker et al., “Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial,” Journal of the American Medical Association, vol. 300, no. 9, pp. 1027–1037, 2008.
[10]  L. D. Baker, L. L. Frank, K. Foster-Schubert et al., “Effects of aerobic exercise on mild cognitive impairment: a controlled trial,” Archives of Neurology, vol. 67, no. 1, pp. 71–79, 2010.
[11]  L. S. Nagamatsu, T. C. Handy, C. L. Hsu, and T. Liu-Ambrose, “Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment,” Archives of Internal Medicine, vol. 172, no. 8, pp. 666–668, 2012.
[12]  J. C. Smith, K. A. Nielson, J. L. Woodard et al., “Does physical activity influence semantic memory activation in amnestic mild cognitive impairment?” Psychiatry Research, vol. 193, no. 1, pp. 60–62, 2011.
[13]  R. C. Cassilhas, K. S. Lee, J. Fernandes et al., “Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms,” Neuroscience, vol. 202, pp. 309–317, 2012.
[14]  S. Colcombe and A. F. Kramer, “Fitness effects on the cognitive function of older adults: a meta-analytic study,” Psychological Science, vol. 14, no. 2, pp. 125–130, 2003.
[15]  Z. S. Nasreddine, N. A. Phillips, V. Bédirian et al., “The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment,” Journal of the American Geriatrics Society, vol. 53, no. 4, pp. 695–699, 2005.
[16]  M. P. Lawton and E. M. Brody, “Assessment of older people: self-maintaining and instrumental activities of daily living,” Gerontologist, vol. 9, no. 3, pp. 179–186, 1969.
[17]  R. A. Washburn, E. McAuley, J. Katula, S. L. Mihalko, and R. A. Boileau, “The Physical Activity Scale for the Elderly (PASE): evidence for validity,” Journal of Clinical Epidemiology, vol. 52, no. 7, pp. 643–651, 1999.
[18]  J. A. Yesavage, “Geriatric depression scale,” Psychopharmacology Bulletin, vol. 24, no. 4, pp. 709–710, 1988.
[19]  D. L. Groll, T. To, C. Bombardier, and J. G. Wright, “The development of a comorbidity index with physical function as the outcome,” Journal of Clinical Epidemiology, vol. 58, no. 6, pp. 595–602, 2005.
[20]  M. D. Lezak, Neuropsychological Assessment, Oxford University Press, New York, NY, USA, 3rd edition, 1995.
[21]  K. I. Erickson, M. W. Voss, R. S. Prakash et al., “Exercise training increases size of hippocampus and improves memory,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 7, pp. 3017–3022, 2011.
[22]  M. W. Voss, K. I. Erickson, R. S. Prakash et al., “Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?” Neuropsychologia, vol. 48, no. 5, pp. 1394–1406, 2010.
[23]  K. I. Erickson, R. S. Prakash, M. W. Voss et al., “Aerobic fitness is associated with hippocampal volume in elderly humans,” Hippocampus, vol. 19, no. 10, pp. 1030–1039, 2009.
[24]  S. Heo, R. S. Prakash, M. W. Voss et al., “Resting hippocampal blood flow, spatial memory and aging,” Brain Research, vol. 1315, pp. 119–127, 2010.
[25]  T. Liu-Ambrose, K. M. Khan, J. J. Eng, P. A. Janssen, S. R. Lord, and H. A. McKay, “Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial,” Journal of the American Geriatrics Society, vol. 52, no. 5, pp. 657–665, 2004.
[26]  G. Borg, “Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling srength test,” International Journal of Sports Medicine, vol. 3, no. 3, pp. 153–158, 1982.
[27]  R. Persinger, C. Foster, M. Gibson, D. C. W. Fater, and J. P. Porcari, “Consistency of the Talk Test for exercise prescription,” Medicine and Science in Sports and Exercise, vol. 36, no. 9, pp. 1632–1636, 2004.
[28]  C. Foster, J. P. Porcari, J. Anderson et al., “The talk test as a marker of exercise training intensity,” Journal of Cardiopulmonary Rehabilitation and Prevention, vol. 28, no. 1, pp. 24–30, 2008.
[29]  ICH Expert Working Group, “ICH Harmonised Tripartite Guideline: statistical principals in clinical trials,” Statistics in Medicine, vol. 18, pp. 1905–1942, 1999.
[30]  A. C. Pereira, D. E. Huddleston, A. M. Brickman et al., “An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 13, pp. 5638–5643, 2007.
[31]  P. M. Greenwood, T. Sunderland, C. Lambert, and R. Parasuraman, “Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the National Institute of Mental Health's BIOCARD study,” Neuropsychology, vol. 19, no. 2, pp. 199–211, 2005.
[32]  M. L. Smith and B. Milner, “The role of the right hippocampus in the recall of spatial location,” Neuropsychologia, vol. 19, no. 6, pp. 781–793, 1981.
[33]  I. J. Rhyu, J. A. Bytheway, S. J. Kohler et al., “Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys,” Neuroscience, vol. 167, no. 4, pp. 1239–1248, 2010.
[34]  A. Parachikova, K. E. Nichol, and C. W. Cotman, “Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition,” Neurobiology of Disease, vol. 30, no. 1, pp. 121–129, 2008.
[35]  E. V. Cyarto, N. T. Lautenschlager, P. M. Desmond et al., “Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial,” BMC Psychiatry, vol. 12, article 167, 2012.

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