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PLOS ONE  2014 

The Associations between Serum Brain-Derived Neurotrophic Factor, Potential Confounders, and Cognitive Decline: A Longitudinal Study

DOI: 10.1371/journal.pone.0091339

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Abstract:

Brain-derived neurotrophic factor (BDNF) plays a role in the maintenance and function of neurons. Although persons with Alzheimer’s disease have lower cortical levels of BDNF, evidence regarding the association between circulating BDNF and cognitive function is conflicting. We sought to determine the correlates of BDNF level and whether BDNF level was prospectively associated with cognitive decline in healthy older adults. We measured serum BDNF near baseline in 912 individuals. Cognitive status was assessed repeatedly with the modified Mini-Mental Status Examination and the Digit Symbol Substitution test over the next 10 years. We evaluated the association between BDNF and cognitive decline with longitudinal models. We also assessed the association between BDNF level and demographics, comorbidities and health behaviors. We found an association between serum BDNF and several characteristics that are also associated with dementia (race and depression), suggesting that future studies should control for these potential confounders. We did not find evidence of a longitudinal association between serum BDNF and subsequent cognitive test trajectories in older adults, although we did identify a potential trend toward a cross-sectional association. Our results suggest that serum BDNF may have limited utility as a biomarker of prospective cognitive decline.

References

[1]  Alderson RF, Alterman AL, Barde YA, Lindsay RM (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 5: 297–306. doi: 10.1016/0896-6273(90)90166-d
[2]  Ghosh A, Carnahan J, Greenberg ME (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263: 1618–1623. doi: 10.1126/science.7907431
[3]  Bramham CR, Messaoudi E (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76: 99–125. doi: 10.1016/j.pneurobio.2005.06.003
[4]  Fahnestock M (2011) Brain-derived neurotrophic factor: the link between amyloid-β and memory loss. Future Neurology 6: 627–639. doi: 10.2217/fnl.11.44
[5]  Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, et al. (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7: 695–702. doi: 10.1016/0896-6273(91)90273-3
[6]  Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M (2000) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 76: 347–354. doi: 10.1016/s0169-328x(00)00023-1
[7]  Peng S, Wuu J, Mufson EJ, Fahnestock M (2005) Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93: 1412–1421. doi: 10.1111/j.1471-4159.2005.03135.x
[8]  Hock C, Heese K, Hulette C, Rosenberg C, Otten U (2000) Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 57: 846–851. doi: 10.1001/archneur.57.6.846
[9]  Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 9: 2459–2464.
[10]  Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, et al. (2002) Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87: 728–734.
[11]  Pan W, Banks Wa, Fasold MB, Bluth J, Kastin aJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37: 1553–1561. doi: 10.1016/s0028-3908(98)00141-5
[12]  Poduslo JF, Curran GL (1996) Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors NGF, CNTF, NT-3, BDNF. Molecular Brain Research 36: 280–286. doi: 10.1016/0169-328x(95)00250-v
[13]  Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, et al. (2007) BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. Journal of psychiatric research 41: 387–394. doi: 10.1016/j.jpsychires.2006.01.014
[14]  Yasutake C, Kuroda K, Yanagawa T, Okamura T, Yoneda H (2006) Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. European archives of psychiatry and clinical neuroscience 256: 402–406. doi: 10.1007/s00406-006-0652-8
[15]  Yu H, Zhang Z, Shi Y, Bai F, Xie C (2008) Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. The Journal of clinical psychiatry: 1104–1111.
[16]  Angelucci F, Spalletta G, Iulio F, Ciaramella a, Salani F, et al. (2010) Alzheimers Disease (AD) and Mild Cognitive Impairment (MCI) Patients are Characterized by Increased BDNF Serum Levels. Current Alzheimer Research 7: 15–20. doi: 10.2174/156720510790274473
[17]  Laske C, Stransky E, Leyhe T, Eschweiler GW, Wittorf a, et al. (2006) Stage-dependent BDNF serum concentrations in Alzheimer's disease. Journal of neural transmission 113: 1217–1224. doi: 10.1007/s00702-005-0397-y
[18]  O'Bryant SE, Hobson VL, Hall JR, Barber RC, Zhang S, et al. (2011) Serum brain-derived neurotrophic factor levels are specifically associated with memory performance among Alzheimer's disease cases. Dementia and geriatric cognitive disorders 31: 31–36. doi: 10.1159/000321980
[19]  Ziegenhorn Aa, Schulte-Herbrüggen O, Danker-Hopfe H, Malbranc M, Hartung H-D, et al. (2007) Serum neurotrophins–a study on the time course and influencing factors in a large old age sample. Neurobiology of aging 28: 1436–1445. doi: 10.1016/j.neurobiolaging.2006.06.011
[20]  Laske C, Stellos K, Hoffmann N, Stransky E, Straten G, et al. (2011) Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. The international journal of neuropsychopharmacology/official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 14: 399–404. doi: 10.1017/s1461145710001008
[21]  Driscoll I, Martin B, An Y, Maudsley S, Ferrucci L, et al. (2012) Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults. PloS one 7: e35217. doi: 10.1371/journal.pone.0035217
[22]  Bus Baa, Molendijk ML, Penninx BJWH, Buitelaar JK, Kenis G, et al. (2011) Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 36: 228–239. doi: 10.1016/j.psyneuen.2010.07.013
[23]  Molendijk ML, Haffmans JP, Bus BA, Spinhoven P, Penninx BW, et al. (2012) Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. PLoS One 7: e48046. doi: 10.1371/journal.pone.0048046
[24]  Murphy PW, Davis TC, Long SW, Jackson RH, Decker BC (1993) Rapid Estimate of Adult Literacy in Medicine (REALM): A quick reading test for patients. Journal of Reading 37: 124–130.
[25]  Teng EL, Chui HC (1987) The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 48: 314–318.
[26]  Wechsler D (1997) Wechsler Adult Intelligence Scale - Third Edition (WAIS-III). San Antonio, TX: The Psychological Corporation.
[27]  Leyhe T, Stransky E, Eschweiler GW, Buchkremer G, Laske C (2008) Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 258: 124–128. doi: 10.1007/s00406-007-0764-9
[28]  Currie J, Ramsbottom R, Ludlow H, Nevill A, Gilder M (2009) Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women. Neuroscience letters 451: 152–155. doi: 10.1016/j.neulet.2008.12.043
[29]  Minelli A, Zanardini R, Bonvicini C, Sartori R, Pedrini L, et al. (2011) BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects. European archives of psychiatry and clinical neuroscience 261: 323–329. doi: 10.1007/s00406-011-0189-3
[30]  Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, et al. (2008) Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. Journal of geriatric psychiatry and neurology 21: 166–170. doi: 10.1177/0891988708316860
[31]  Lang UE, Hellweg R, Gallinat J (2004) BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology 29: 795–798. doi: 10.1038/sj.npp.1300382
[32]  Jung SH, Kim J, Davis JM, Blair SN, Cho H-c (2011) Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men. European journal of applied physiology 111: 303–311. doi: 10.1007/s00421-010-1658-5
[33]  Li G, Peskind ER, Millard SP, Chi P, Sokal I, et al. (2009) Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. PloS one 4: e5424. doi: 10.1371/journal.pone.0005424
[34]  Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, et al. (2011) Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 14: 347–353. doi: 10.1017/s1461145710000738
[35]  Sen S, Duman R, Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biological psychiatry 64: 527–532. doi: 10.1016/j.biopsych.2008.05.005

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