Interleukin-10 (IL-10) is an important cytokine that
plays a pivotal role in natural and adaptive immune systems. However, in lower
vertebrates, especially in teleost the receptor of this cytokine is still
largely unknown. This paper described the cloning and characterization of grass
carp interleukin-10 receptor 1 (gcIL10R1) and the 3D structure of its
extracellular domain was predicted. The gcIL10R1 cDNA included 180 bp5’ untranslated region (UTR), 870 bp3’ UTR and an open reading frame (ORF) of
1632 bp. The ORF was found to encode a 543 amino acid protein with a putative
JAK1 binding site, one STAT3 binding site. The phylogenetic analysis clusters
gcIL10R1 with other teleost IL10R1s but independently of the amphibian, avian
and mammalian IL10R1s. The 3D structure of its extracellular domain was the
first homology model of a fish IL10R1 that revealed a high similarity with its
mammalian and avian counterparts.
D. F. Fiorentino, M. W. Bond and T. R. Mosmann, “Two Types of Mouse T Helper Cell. IV. Th2 Clones Secrete a Factor That Inhibits Cytokine Production by Th1 Clones,” The Journal of Experimental Medicine, Vol. 170, 1989, pp. 2081-2095.
D. F. Fiorentino, A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore and A. O’Garra, “IL-10 Acts on the Antigen-Presenting Cell to Inhibit Cytokine Pro- duction by Th1 Cells,” The Journal of Immunology, Vol. 146, 1991, pp. 3444-3451.
R. de Waal Malefyt, J. Abrams, B. Bennett, C. G. Figdor and J. E. de Vries, “Interleukin 10(IL-10) Inhibits Cytokine Synthesis by Human Monocytes: An Autoregulatory Role of IL-10 Produced by Monocytes,” The Journal of Experimental Medicine, Vol. 174, 1991, 1991, pp. 1209- 1220. http://dx.doi.org/10.1084/jem.174.5.1209
A. D’Andrea, M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin and G. Trinchieri, “Interleukin 10 (IL-10) Inhibits Human Lymphocyte Interferon Gamma-Production by Suppressing Natural Killer Cell Stimulatory Factor/ IL-12 Synthesis in Accessory Cells,” The Journal of Ex- perimental Medicine, Vol. 178, 1993, pp. 1041-1048.
N. Schuetze, S. Schoeneberger, U. Mueller, M. A. Freudenberg, G. Alber and R. K. Straubinger, “IL-12 Family Members: Differential Kinetics of Their TLR4-Mediated Induction by Salmonella enteritidis and the Impact of IL-10 in Bone Marrow-Derived Macrophages,” International Immunology, Vol. 17, 2005, pp. 649-659.
H. Wei, M. Yang, T. Zhao, X. Wang and H. Zhou, “Functional Expression and Characterization of Grass Carp IL-10: An Essential Mediator of TGF-Beta1 Immune Regulation in Peripheral Blood Lymphocytes,” Molecular Immunology, Vol. 53, 2013, pp. 313-320.
G. Lutfalla, K. Gardiner and G. Uze, “A New Member of the Cytokine Receptor Gene Family Maps on Chromosome 21 at Less than 35 kb from IFNAR,” Genomics, Vol. 16, 1993, pp. 366-373.
A. S. Ho, Y. Liu, T. A. Khan, D. H. Hsu, J. F. Bazan and K. W. Moore, “A Receptor for Interleukin 10 Is Related to Interferon Receptors,” Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, 1993, pp. 11267-1171.
S. V. Kotenko, “The Family of IL-10-Related Cytokines and Their Receptors: Related, but to What Extent?” Cytokine & Growth Factor Reviews, Vol. 13, 2002, pp. 223-240. http://dx.doi.org/10.1016/S1359-6101(02)00012-6
M. R. Walter, W. T. Windsor, T. L. Nagabhushan, D. J. Lundell, C. A. Lunn, P. J. Zauodny and S. K. Narula, “Crystal Structure of a Complex between Interferon-Gamma and Its Soluble High-Affinity Receptor,” Nature, Vol. 376, 1995, pp. 230-235.
R. M. Weber-Nordt, J. K. Riley, A. C. Greenlund, K. W. Moore, J. E. Darnell and R. D. Schreiber, “Stat3 Recruitment by Two Distinct Ligand-Induced, Tyrosine-Phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain,” The Journal of Biological Chemistry, Vol. 271, 1996, pp. 27954-27961.
L. Rothwell, J. R. Young, R. Zoorob, C. A. Whittaker, P. Hesketh, A. Archer, A. L. Smith and P. Kaiser, “Cloning and Char-acterization of Chicken IL-10 and Its Role in the Immune Response to Eimeria maxima,” The Journal of Immunology, Vol. 173, 2004, pp. 2675-2682.
M. Chadzinska, E. Kolaczkowska, A. Scislowska-Czarnecka, N. Van Rooijen and B. Plytycz, “Effects of Macrophage Depletion on Peritoneal Inflammation in Swiss Mice, Edible Frogs and Goldfish,” Folia Biologica (Kra-kow), Vol. 52, 2004, pp. 225-231.
J. Zou, M. S. Clark and C. J. Secombes, “Characterisation, Expression and Promoter Analysis of an Interleukin 10 Homologue in the Puffer Fish, Fugu rubripes,” Immunogenetics, Vol. 55, 2003, pp. 325-335.
R. Savan, D. Igawa and M. Sakai, “Cloning, Characterization and Expression Analysis of Interleukin-10 from the Common Carp, Cyprinus carpio L.,” European Journal of Biochemistry, Vol. 270, 2003, pp. 4647-4654.
Y. Inoue, S. Kamota, K. Ito, Y. Yoshiura, M. Ototake, T. Moritomo and T. Nakanishi, “Molecular Cloning and Expression Analysis of Rainbow Trout (Oncorhynchus my-kiss) Interleukin-10 cDNAs,” Fish and Shellfish Immunology, Vol. 18, 2005, pp. 335-344.
D. C. Zhang, Y. Q. Shao, Y. Q. Huang and S. G. Jiang, “Cloning, Characterization and Expression Analysis of Interleu-kin-10 from the Zebrafish (Danio rerion),” Journal of Biochemistry and Molecular Biology, Vol. 38, 2005, pp. 571-576.
L. Grayfer and M. Belosevic, “Identification and Mole- cular Characterization of the Interleukin-10 Receptor 1 of the Zebrafish (Danio rerio) and the Goldfish (Carassius auratus L.),” Developmental & Comparative Immunology, Vol. 36, 2012, pp. 408-417.
J. D. Bendtsen, H. Nielsen, G. von Heijne and S. Brunak, “Improved Prediction of Signal Peptides: SignalP 3.0,” Journal of Molecular Biology, Vol. 340, pp. 783-795.
S. Kumar, K. Tamura and M. Nei, “MEGA3: Integrated Software for Molecular Evolutionary Genetics Analysis and Sequence Alignment,” Briefings in Bioinformatics, Vol. 5, 2004, pp. 150-163.
A. Usacheva, R. Sandoval, P. Domanski, S. V. Kotenko, K. Nelms, M. A. Goldsmith and O. R. Colamonici, “Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation,” The Journal of Biological Chemistry, Vol. 277, 2002, pp. 48220- 48226. http://dx.doi.org/10.1074/jbc.M205757200
A. Usacheva, S. Kotenko, M. M. Witte and O. R. Colamonici, “Two Distinct Domains within the N-Terminal Region of Janus Kinase 1 Interact with Cytokine Receptors,” The Journal of Immunology, Vol. 169, 2002, pp. 1302-1308.
A. M. O’Farrell, Y. Liu, K. W. Moore and A. L. Mui, “IL-10 Inhibits Macrophage Activation and Proliferation by Distinct Signaling Mechanisms: Evidence for Stat3-Dependent and-Independent Pathways,” EMBO Journal, Vol. 17, 1998, pp. 1006-1018.
J. K. Riley, K. Takeda, S. Akira and R. D. Schreiber, “Interleukin-10 Receptor Signaling through the JAK- STAT Pathway. Requirement for Two Distinct Receptor-Derived Signals for Anti-Inflammatory Action,” The Journal of Biological Chemistry, Vol. 274, 1999, pp. 16513-16521. http://dx.doi.org/10.1074/jbc.274.23.1651