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The Potential Effect of Special Formulas on Cirrhotic Rats

DOI: 10.4236/fns.2013.45077, PP. 594-603

Keywords: Liver Cirrhosis, CCl4, Formulas, Liver Function, Histopathological, Hepatoprotective

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Abstract:

Liver protective effect of special formulas (1 and 2) was assessed against carbon tetra chloride (CCl4) which induced liver damage in Wister albino rats. The two prepared formulas reduced the changes in body weight and liver weight caused by CCl4 in rats. The toxicity of CCl4 is related to loss in body weight and increase in liver weight in rats. The weight ratios of liver to body weight (LW/BW) significantly increased in rats treated with CCl4 followed by other groups. Formulas 1 and 2 could play an important role in improvement of hematological indices in liver cirrhosis rats. Feeding treated rats on special formulas showed improvement in liver function compared to rats fed on basal diet, reflected by significant reduction of the activity of transaminases (ALT and AST), alkaline phosphatase (ALP) and total bilirubin. There was a significant increase in total protein, albumin and globulin in serum. Significant increase in liver weight in rats treated with CCl4. There are no histopathological changes in all groups under study except for group 4 (CCl4 treated rats fed on basal diet) which orally administrated with CCl4 and had congestion of central vein and hepatic sinusoids.

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