All Title Author
Keywords Abstract

Breast cancer in pregnancy; routine examination, diagnosis and management: A case report

DOI: 10.4236/crcm.2013.22031, PP. 119-122

Keywords: Pregnancy, Breast Cancer, Screening, Multidisciplinary Management

Full-Text   Cite this paper   Add to My Lib


Pregnancy associated breast cancer is defined as breast cancer diagnosed during pregnancy or in the first postpartum year. The incidence is rare; however it is important to be aware of its occurrence with the increased challenges posed by delays in diagnosis, treatment and optimization of maternal and fetal outcomes. The case report presented is of a 36 years old, Para 0 + 2 known diabetic and hypertensive pregnant woman, first seen in the antenatal clinic at 14 weeks of gestation. The patient requested for a breast examination following National campaigns conducted during the International Breast Cancer Awareness month. The examination revealed a grossly enlarged right breast with “peau de orange” skin changes. The patient eventually underwent radical mastectomy. Histopathology revealed a grade 3 invasive ductal carcinoma with lymphovascular invasion (Stage TNM). This case is presented to highlight missed opportunities in antenatal clinic settings for screening, diagnosis and treatment of cancer of the breast in pregnancy. The role of a multidisciplinary approach to management has also been emphasized.


[1]  Keyser, E.A., Staat, B.C., Fausett, M.B. and Shields, A.D. (2012) Pregnancy-associated breast cancer. Reviews in Obstetrics and Gynecology, 5, 94-99.
[2]  Salzman, B., Fleegle, S. and Tully, A.S. (2012) Common breast problems. American Family Physician, 86, 343-349.
[3]  Woo, J.C., Yu, T. and Hurd, T.C. (2003) Breast cancer in pregnancy: A literature review. Archives of Surgery, 138, 91-98.
[4]  Theriault, R. and Hahn, K. (2007) Management of breast cancer in pregnancy. Current Oncology Reports, 9, 17-21. doi:10.1007/BF02951421
[5]  Liberman, L., Giess, C.S., Dershaw, D.D., Deutch, B.M. and Petrek, J.A. (1994) Imaging of pregnancy-associated breast cancer. Radiology, 191, 245-248.
[6]  Hassiotou, F. and Geddes, D. (2012) Anatomy of the human mammary gland: Current status of knowledge. Clinical Anatomy, 26, 29-48. doi:10.1002/ca.22165
[7]  Azim Jr., H.A., Santoro, L., Russell-Edu, W., Pentheroudakis, G., Pavlidis, N. and Peccatori, F.A. (2012) Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies. Cancer Treatment Reviews, 38, 834-842. doi:10.1016/j.ctrv.2012.06.004
[8]  Zagouri, F., Sergentanis, T.N., Chrysikos, D., Dimitrakakis, C., Tsigginou, A., Zografos, C.G., Dimopoulos, M.A. and Papadimitriou, C.A. (2012) Taxanes for breast cancer during pregnancy: A systematic review. Clinical Breast Cancer.
[9]  Cordoba, O., Llurba, E., Saura, C., Rubio, I., Ferrer, Q., Cortes, J. and Xercavins, J. (2012) Multidisciplinary approach to breast cancer diagnosed during pregnancy: Maternal and neonatal outcomes. Breast. doi:10.1016/j.breast.2012.10.005
[10]  Brewer, M., Kueck, A. and Runowicz, C.D. (2011) Chemotherapy in pregnancy. Clinical Obstetrics and Gynecology, 54, 602-618. doi:10.1097/GRF.0b013e318236e9f9
[11]  Lenhard, M.S., Bauerfeind, I. and Untch, M. (2008) Breast cancer and pregnancy: Challenges of chemotherapy. Critical Reviews in Oncology/Hematology, 67, 196-203. doi:10.1016/j.critrevonc.2008.02.007
[12]  Daniilidis, A., Giannoulis, C., Sardeli, C., Dinas, K., Nasioutziki, M., Tantanasis, T., Loufopoulos, A. and Tzafettas, J. (2010) Pregnancy-associated breast cancer—A review analysis. European Journal of Gynaecological Oncology, 31, 485-490.
[13]  Amant, F., Loibl, S., Neven, P. and Van Calsteren, K. (2012) Breast cancer in pregnancy. Lancet, 379, 570-579. doi:10.1016/S0140-6736(11)61092-1
[14]  Cardonick, E., Gilmandyar, D. and Somer, R.A. (2012) Maternal and neonatal outcomes of dose-dense chemotherapy for breast cancer in pregnancy. Obstetrics & Gynecology, 120, 1267-1272.
[15]  Keleher, A.J., Theriault, R.L., Gwyn, K.M., Hunt, K.K., Stelling, C.B., Singletary, S.E., Ames, F.C., Buchholz, T.A., Sahin, A.A. and Kuerer, H.M. (2002) Multidisciplinary management of breast cancer concurrent with pregnancy. rnal of the American College of Surgeons, 194, 54-64. doi:10.1016/S1072-7515(01)01105-X
[16]  Slingerland, M., Kroep, J., Liefers, G.J., Scholten, A. and Nortier, J.W. (2012) Pregnancy-associated breast cancer: Current opinions on diagnosis and treatment. Nederlands Tijdschrift voor Geneeskunde, 156, A5286.


comments powered by Disqus