Introduction: Skin of phototypes IV to VI according to Fitzpatrick represents the majority of the world's population. Clinically, the features of photoaging in African can include fine wrinkling, mottled pigmentation, and dermatosis papulosa nigra (DPN). All studies have confirmed the effectiveness and low risk of complication associated with use of Nd: YAG laser in dark skin patients. Objectives: This study aimed to detect the effectiveness of Nd: YAG laser, 1064 nm, with specific laser parameters, in the treatment of dermatosis papulosa nigra (DPN) in some Sudanese patients. Material and methods: Twenty patients, clinically diagnosed as cases of dermatosis papulosa nigra, were selected from different dermatology clinics in Khartoum state and were considered as study population. Nd: YAG laser, with 1064 nm wavelength, was used in this study. The laser parameters were: non-contact applications of bare fiber, power of 25 Watt and duty cycle of 0.2 second. The number of exposure intervals delivered per lesion was chosen according to the size of papules. The data was analyzed using SPSS 15.0, and p-value of p<0.05 had been used. Results: Relationship of the treatment response and Northern tribes was found statistically relevant (p<0.05). Three and six weeks after the last session, evaluation of patients response was as following: - Excellent response in 17 patients (85%), - Very good in 3 patients (15%), - Good (0.0%), - Bad (0.0%), - No response (0.0%). Conclusions: This study proved that the use of Nd: YAG laser 1064 nm, with certain parameters could achieve excellent or very good results in all patients.