This study assessed the relationship between social support and mental health (depression, anxiety and somatic anxiety) relative to its impact on managerial women in Ghana. The objective is to seek answers to the question as to whether the availability of social support in the work environment can help improve the mental health of women. This is because the lack of spousal support for working women is found to have a direct connection to diminished mental health. The findings show that spousal support provided women with a sense of security and stability at home and also reduced their possibility of being confronted with role conflict. It is thus, concluded that the career progression of women managers can be greatly enhanced when they receive spousal support, encouragement and guidance in addition to those from superiors and co-workers.