全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Reactivation of acetycholinesterase inhibited by the pesticide chlorpyrifos

Keywords: Acetylcholinesterase , reactivator , pesticide , organophosphate

Full-Text   Cite this paper   Add to My Lib

Abstract:

Organophosphorus pesticides such as parathion or chlorpyrifos are substances used worldwide foragricultural purposes. These compounds are able to inhibit an enzyme acetylcholinesterase (AChE; EC3.1.1.7) by phosphorylation in its active site. AChE reactivators and anticholinergics are generally used asantidotes in the case of intoxication by these agents. In this work, the reactivation potency of ninestructurally different AChE reactivators was tested in vitro. Chlorpyrifos was chosen as an appropriatemember of the pesticide family. The result is that bisquaternary reactivators with two oxime groups inposition four at the pyridinium rings (trimedoxime and K074) seem to be the most potent reactivators ofchlorpyrifos-inhibited AChE.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133