This study investigated the phytochemical composition of Globimetulla browni for its ascribed folkloric medicinal uses as an antidiabetic and to establish it’s antibacterial potency (if any) during the dry season (Between the months of October - April). A comparative analysis was however made and season had little or no significant effect on the phytochemical / antibacterial potency of this plant extract. The ethanolic and aqueous extracts significantly affected both Gram-positive and Gram- negative microorganism during dry season. Globimetulla browni is a specie of African mitletoe and is hemi-parasitic in nature growing on many trees e.g., Eukalyptus and has ascribed medicinal uses. Phytochemical screening showed the presence of carbohydrates, alkaloids, tannins and flavonoids. The ethanolic and aqueous extracts inhibited the growth of Klebsiella aerogenes, Proteus spp., Escherichia coli and Pseudomonas aeruginosa. Gentamycin and Cloxacillin did not exhibit any activity against Pseudomonas aeruginosa.