The experiment was conducted during six cropping seasons (1997/98 to 2002/03), with the objective to study the relationships between grain yield performance, temporal stability and carbon isotope discrimination of durum wheat (Triticum durum Desf.) genotypes grown under semi-arid conditions of the eastern highlands of Algeria. The results indicated significant season and genotype x season interaction for grain yield and a non significant genotypic main effect. Mrb5 cultivar out yielded the evaluated entries during three out of six cropping seasons, Cyprus 1, Bicre and Daki were the top-yielding genotypes in two seasons and Waha, Belikh 2 and Heider/ Martes// Huevos de Oro, were high yielding during only one cropping season. Heider and Mrb16 showed a relatively high grain yield temporal stability, Derraa had the lowest value. The results of the present study indicated that grain yield measured during six cropping seasons was not significantly correlated with Δ13C measured during one season. This suggested that carbon isotope discrimination could not be suggested as an indirect selection criterion to screen durum wheat genotypes for water use efficiency under the Mediterranean climate of the high plateaus of Algeria.