Centrifugal spinning (C-spin) is one of the emerging techniques for the production of ultrafine fibrous web which mimics Extracellular matrix (ECM). Due to its unique characteristic features it is widely used in bio-medical applications such as tissue engineered scaffolds, wound dressing materials and drug delivery vehicles. In the present study tetracycline loaded polycaprolactone (PCL) blended polyvinyl pyrrolidone (PVP) fibers were fabricated using in-house built C-spin system. The developed ultrafine fibers were morphologically characterized by Scanning Electron Microscope (SEM) before and after drug release and the results showed that the developed webs were highly porous and the pores were evenly distributed. Fourier Transform Infrared (FTIR) spectroscopy results confirmed that the drug was incorporated on the fibers. The antibacterial activity and drug releasing strategy were examined and the results showed that the developed webs can effectively act as a drug delivery vehicle.