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Cell cycle checkpoints: methods and protocols

DOI: 10.4081/ejh.2012.br10

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As it is well known at the end of each cell cycle step there are checkpoints to verify that DNA duplication and segregation (among other events) met every requirements before the cell is allowed to proceed to the next step. Multiple signaling molecules, notably cyclins and the cyclin-dependent kinases (CDKs), play major roles in the cell cycle checkpoint’s control....


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