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Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety

DOI: 10.5155/eurjchem.1.3.168-172.29

Keywords: 1 , 2 , 4-Triazine , 1 , 2 , 4-Triazole , Imidazole , Polyheterocyclic nitrogen systems , Antimicrobial activity

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Abstract:

7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1,4-dihydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.

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