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The Effects of Simultaneous 8 Weeks Astragalus sp/ Euphorbia Cheriradenia Honey Supplementation and Endurance Training on Membrane Lipid Peroxidation of Erythrocytes after a Bout Acute Exhaustive Treadmill Exercise in Rats

Keywords: endurance training , erythrocyte , exhaustive exercise , SOD , lipid peroxidation

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Strenuous exercise is known to induce oxidative stress leading to the generation of free radicals. The purpose of the present study was to investigate the effects of honey, at a dose (1.5 g/kg weight per d) on the MDA and SOD levels of plasma in rats after exhaustive exercise. Male rats (n=48) were divided into four groups, group 1, sedentary with distilled water (Sed -DW n=12), group 2, sedentary control with honey (Sed-H N=12), group 3, exercise trained with distilled water (ET-WD n=12), group 4, exercise trained with honey (ET- H n=12) groups. Four groups were further divided equally into two groups where the rats were studied at rest and immediately after exhaustive exercise. During the training period, groups 2 4 were treated with 1.5 g/kg body weight honey, freshly diluted by distilled water to 50% and the other groups 1 3 were treated with distilled water (1 ml) just before each administration intragastrically tube daily at 8:00 to rats / once daily for 8 weeks. Endurance training consisted of treadmill running 1.5 h day-1, 5 days a week for 8 weeks, reaching the speed of 2.1 kmh-1at the fourth week. For acute exhaustive exercise, graded treadmill running was conducted reaching the speed of 2.1 km h-1 at the 95th min, 10% uphill, and was continued until exhaustion. Erythrocyte MDA level was significantly increased after exhaustion in groups 1 3 but not in groups 2 4 animals compared with the corresponding sedentary rest. Honey treatment caused a significant decrease in MDA levels of groups 2 4 compared to the groups 1 3 animals. While acute exhaustive exercise decreased erythrocyte SOD activity in subgroups 1 3 rats, it increased the activity of this enzyme in groups 2 4 rats. Treadmill training increased the endurance time in trained rats compared with sedentary rats. The results of this study suggest that honey supplementation may be useful to prevent acute exhaustive exercise-induced oxidative stress in erythrocytes by up-regulating some of the antioxidant enzyme activities and may have implications in exercising humans.


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