Numerous treatment approaches exist within manual and manipulative therapy for the management of a variety of musculoskeletal and non-musculoskeletal conditions. Most of the techniques such as manipulation, muscle energy techniques, positional release techniques, myofascial release techniques and craniosacral therapy, which are also commonly used in manual therapy. Traditionally osteopathy developed the “art” and "science" of these techniques while most of the research supporting their use in clinical practice is now published by physical therapists. Orthopaedic Manual Physical Therapy encompasses the so-called bridge for the plausible gap between the two professions. While osteopaths work under the somatic dysfunction model and physical therapists under the pain and movement model, the recent International Association for the Study of Pain (IASP) global year against musculoskeletal pain emphasized the “biopsychosocial model.” The biopsychosocial model demands both the professions to work hand-in-hand and to understand mutual responsibilities and roles. Such an inter-professional teamwork would henceforth facilitate better patient recovery and care.