The plants, Trianthema decandra and Glinus oppositifolius are commonly used by tribal people in India for the treatment of cancer. The anticancer activity of methanol extracts of Trianthema decandra(METD) and Glinus oppositifolius(MEGO) was evaluated in Ehrlich Ascites Carcinoma (EAC)cell line injected intraperitoneally (i.p.) to adult Swiss albino mice at the rate of 2 x 106 cells/mouse. The mean survival time, tumor volume, life span, tumor cell count, hemoglobin content and RBC count and WBC count were measured to determine the anticarcinogenic effect of METD and MEGO at the doses of 100, 200 and 400 mgkg body weight of mice administered i.p. The life span of the tumor bearing mice, total number of RBC and haemoglobin content were significantly increased. In differential count of WBC, percentage of lymphocytes was also increased with decreased level of neutrophils in METD and MEGO treated mice. The tumor volume and the percentage of viable cells in ascitic fluid were significantly reduced in METD and MEGO treated mice. From the result of the above-mentioned parameters, it was concluded that METD and MEGO significantly elicited a potent anticancer activity as compared with that of the standard anticancer drug, 5- fluorouracil (5-FU), intraperitoneally at a dose of 2 mg/kg body weight.