BACKGROUND: One of the frequently used measures of research performance of a country or a university is counting the related scientific production. In the present study the number of scientific production including research projects, books, journal articles and conference proceedings published under the name of Isfahan University of Medical Sciences were identified and then compared with those reported by Iranian Ministry of Health and Medical Education for the year 1384. The purpose of this study was to identify one-year research performance of Isfahan University of Medical Sciences and to show the growth rate of scientific production of this university from 1384 to 1385. METHODS: The present cross-sectional study was carried out by reviewing related official documents and running advanced searches in some of the most important databases. The time limitation was set on 1385 hijri shamsi, which is equal to the beginning of April 2006 till the end of March 2007. RESULTS: During the period of the study, Isfahan University of Medical Sciences published 56 books. The total number of approved research projects was 1080, most of which (61.67%) were descriptive studies. A total of 721 journal articles published by the university researchers of which 146 papers were indexed by ISI, 26 papers were indexed by MEDLINE, 194 papers were indexed by EMBASE, Scopus, Biological Abstracts, Chemical Abstracts and CINAHL, 318 articles were indexed by other databases. Only 37 articles published via non-indexed journals. 74.2% of the articles appeared in domestic journals while only 25.8% published in foreign journals. The total number of national and international conference proceedings was 726. The findings showed a significant increase (nearly 100%) in all kinds of scientific productions compared to those published in 1384 except the published books. CONCLUTIONS: The present study indicates that despite suffering from limitations in annual research budgets and facilities, research performance of Isfahan University of Medical Sciences has increased appreciably during the last year. KEY WORDS: Research performance, scientific productivity, scientometrics, information databases.