A study of antimuscarinic agents on skeletal muscle of frog

Some of the known antimuscarinic agents were studied for their effect on the acetylcholine induced contraction of the super-fused skeletal muscle of frog, All drugs exhibited varying degrees of curarimimetic effect. During recovery from the drug effect, the tissue exhibited an increased sensitivity to the action o f acetyl-choline; in some instances it was immediate, but it was only at very small concentrations.