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Islet Isolation and Transplantation from an Annular Pancreas: A Case Report

Keywords: Abnormalities , Adult , Brain Death , Cell Separation , Diabetes Mellitus , Diabetes Mellitus , Type 1 /surgery , Duodenum /anatomy and histology , Humans , Islets of Langerhans , Islets of Langerhans Transplantation , Islets of Langerhans /cytology , Male , Pancreas /abnormalities , Tissue and Organ Procurement

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Abstract:

CONTEXT: Annular pancreas is an uncommon congenital anomaly formed by a thin band of normal pancreatic tissue encircling the duodenum. CASE REPORT: We report the first case of an islet isolation and transplantation from an annular pancreas. The pancreas together with duodenum was procured from a 32-year-old previously healthy man after diagnosis of brain death. The pancreas including the annular portion was distended well after intraductal collagenase perfusion. A total of 276,064 islet equivalent was recovered and transplanted into a type 1 diabetic patient. CONCLUSIONS: Bearing in mind the shortage of donors, patients with this anomalous condition should not be excluded as potential organ donors.

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