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Epidemiology and immunoprotection of nephropathogenic avian infectious bronchitis virus in southern China

DOI: 10.1186/1743-422x-8-484

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Based on epidemiology analysis of recent field isolates of nephropathogenic IB in vaccinated farms in China, YL6 strain were used for vaccination and evaluated by antibody titer and challenge tests. The immunoprotection test indicated that the practical application of vaccine based on the recent field strains could finely facilitate controlling the nephropathogenic IB.Our study was aim at setting a guide for safeguard against nephropathogenic IBV-caused disease in China.Infectious bronchitis (IB) is a serious and highly contagious disease of chickens all over the world. Avian infectious bronchitis virus (IBV) was first reported in the USA for replicating in the respiratory tract and some other epithelial cells of gut, kidney, and oviduct. Subsequently, some strains of IBV caused pathology in non-respiratory organs (such as kidney and gonads) were documented [1]. The clinical disease and production problems frequently cause catastrophic economic losses to the poultry industry, accompanied by decreased production performance in breeder flocks, diminished egg production and poor egg quality in laying flocks [1-3]. In China, IB has a more profound social impact for chicken industrial contributes to the rural economy. More importantly, there is accumulating evidence that nephropathogenic type IB has been more and more prevalent in China recently, but the strains isolated in earlier years mainly caused respiratory signs, which suggested that selecting and immunization with the appropriate vaccine strain is of great importance to control IB infection [4-7].Some researchers reported that satisfactory cross protection could be provided by appropriate vaccine programs against genetically or antigenically unrelated IBVs [8]. However, this symphysial vaccine manner was restricted by the diversity of the IBV strains. Since IBV strains were first isolated and identified in China in 1982, various live-attenuated and inactivated vaccines derived from respiratory-typed strains have


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