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Epidemiologic parameters and evaluation of control measure for 2009 novel influenza a (H1N1) in Xiamen, Fujian Province, China

DOI: 10.1186/1743-422x-9-20

Keywords: Novel influenza A (H1N1), Epidemiologic Parameter, Control Measure, Evaluation

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Abstract:

We determined various parameters from laboratory-confirmed cases, including incubation period, duration of illness and reproductive number (R0), and evaluated the control measures.There were1414 cases with dates of onset between June 14, 2009 and March 22, 2010. The incidence was 56.79/100,000, and mortality was 0.12/100,000. The incidence during the community epidemic phase was 6.23 times higher than in the containment phase. A total of 296,888 subjects were inoculated with domestic influenza H1N1 virus cleavage vaccine. An epidemic curve showed that vaccination in students cut the peak incidence of illness significantly. Men (relative risk (RR) = 1.30, 95% confidence interval (CI): 1.17-1.45) and persons aged 0-14 years were at greater risk of infection. The incidence increased with younger age (χ2 = 950.675, p = ∞). Morbidity was lower in urban than in rural areas (RR = 0.56, 95%CI: 0.50-0.62). The median incubation time was 2 days, median duration of symptoms was 7 days, and the within-school reproductive number was 1.35.Our analysis indicated that the characteristics of this novel influenza virus were similar to those of seasonal influenza. The principle of "interception of imported cases" applied at Xiamen ports, and vaccination of students effectively limited the spread of the influenza pandemic and reduced the epidemic peak.The emergence and global spread of the 2009 H1N1 influenza pandemic was a challenge to control in Xiamen city, Fujian Province, China. This is because the city is situated on the southeast coast of China (Figure 1), which is a special economic zone and sub-provincial area, whose planning is directly linked with central government, and it receives a large number of overseas visitors and holds various international conferences each year.Our prevention and control strategy is different from other countries or regions. The containment strategy was implemented successfully in the early response days and large-scale inoculation with domestic in

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