Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis

Objectives: Increased levels of free radicals and oxidantmolecules and decreased levels of antioxidant moleculeshave been defined in patients with multiple sclerosis(MS). Ischemia-modified albumin (IMA) levels have beenadvocated as a biomarker for evaluating the oxidativestress status. The aim of this study was to investigate therelationship between oxidative stress and MS.Materials and methods: We compared serum ischemiamodified albumin levels and prolidase activity of 42 patientswith MS (30 female, 12 male) and 30 age-matchedhealthy controls (21 female, 9 male).Results: Ischemia modified albumin levels of MS patients(73,07±26,53 ng/mL) were significantly higher than thoseof controls (60,18±18,01 ng/mL) (p=0.024). However,there were no significant differences in prolidase levelsbetween patients and healthy controls (p=0.856).Conclusions: Increased ischemia modified albumin levels,supports the role of oxidative stress in patients withmultiple sclerosis. J Clin Exp Invest 2012; 3(4): 518-520Key words: Multiple sclerosis, ischemia modified albumin,prolidase, oxidative stress