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Colonoscopy-based diagnosis of portal hypertensive colopathy in cirrhotic patients and relation to hepatic disease pathogenesis

Keywords: colonoscopes , liver cirrhosis , esophageal and gastric varices , hypertension , portal

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ObjectiveTo evaluate the rate of colonoscopy-based diagnosis of portal hypertensive colopathy (PHC) in patients with cirrhosis and evaluate associations with the hepatic disease pathogenic features. MethodsTwenty-three cirrhotic patients who underwent colonoscopy between January 2009 and May 2012 were enrolled in the study. The colonoscopy examination results, Child-Pugh scores, esophageal varices stages, and aspartate aminotransferase to platelet ratio index (APRI) values were recorded for each patient. The significance of inter-group differences was assessed by Chi-squared test or Fisher′s exact test. ResultsThe most common colonoscopy finding was PHC (9/23, 39.1%). Only 8.7% (2/23) of patients had completely normal findings. Occurrence of PHC was associated with moderate to severe esophageal varices (P=0.086) but not with severe liver fibrosis, either by APRI index or Child-Pugh score. ConclusionThe majority of cirrhosis patients had anomalous colonoscopy findings, and more than one-third had PHC. Colonoscopy should be considered for cirrhotic patients to identify previously undiagnosed PHC and initiate timely treatment.


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