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Flavonoid from Intsia palembanica as Skin Whitening Agent

Keywords: whitening agent , Instia palembanica , (-)-robidanol , tyrosinase inhibitor , melanin

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This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in B16 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 M; diphenolase 26.6 M) and inhibit melanin synthesis 46.2% compared to control (at 100 M). In conclusion, (-)-robidanol is the best compound as a whitening agent.


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