Flavonoid from Intsia palembanica as Skin Whitening Agent

This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in B16 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 M; diphenolase 26.6 M) and inhibit melanin synthesis 46.2% compared to control (at 100 M). In conclusion, (-)-robidanol is the best compound as a whitening agent.