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NANOCOCHLEATE: AS DRUG DELIVERY VEHICLE

Keywords: Phospholipid , Liposomes , Phagocytosis.

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Abstract:

Nanaocochleate represent a new technology for oral and systemic delivery of drugs. It is a novel lipid-based system which represent a unique technology platform suitable for the oral and systemic administration of a wide variety of molecules with important therapeutic biological activities, including drugs, genes, and vaccine antigens. Nanocochleate formulation technology is particularly applicable to macromolecules as well as small molecule drugs that are hydrophobic, positively charged, negatively charged, and that possess poor oral bioavailability. Proof-of-principle studies for cochleate-mediated oral delivery of macromolecules as well as small molecule drugs is being carried out in appropriate animal models with well established, clinically important drugs, which currently can only be effectively delivered by injection.

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