DISSOLUTION IMPROVEMENT OF POORLY WATER SOLUBLE DRUG BY FREEZE DRYING WITH PVP K-30

This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in polyvinylpyrrolidone (PVP) K30 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:PVP K30 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and PVP K30 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. Theamorphous state of CFX coupled with presence of interaction between drug and PVP K30. However, he antimicrobial activity of CFX was increased significantly by PVP K-30 against S. aureus and E.coli. The solid dispersion technique of CFX:PVP K-30 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.