This study was carried out to determine the expected role of liquorice to be involved in alleviate the detrimental effects of aflatoxicosis on physiological performance of broiler chickens. A total of 900 Fawbro broiler chicks, three weeks old were used in this study. Chicks were randomly allocated to 6 treatments of 3 replicates per each treatment. Birds in the first treatment (T1) were fed a basal diet and used as control group. Birds in T2 treatment fed a basal diet contaminated with aflatoxin , while birds in T3 treatment were fed a diet contaminated with aflatoxin and treated with mold killer. However, birds in T4, T5 and T6 treatments were fed a diet contaminated with aflatoxin and supplemented with liquorice extract at the levels of 150, 300 and 450 mg / kg of diet, respectively.Results of this study revealed that dietary aflatoxin (T2) significantly (p < 0.05) decreased erythrocyte counts (RBC), haemoglobin concentration (Hb) , hematocrit (PCV), thrombocyte counts (Thr), leukocyte counts (WBC), plasma glucose (Glu), plasma protein (Pro), plasma calcium (Cal), plasma phosphorous (Pho) and alkaline phosphatase (ALP) activity, while significant (p < 0.05) increases were found in heterophil / lymphocyte ratio (H / L), plasma uric acid (Uri), plasma cholesterol (Cho) , and aspartate aminotransaminase (AST) activity compared with control group (T1) .The addition of liquorice extract (T4, T5 and T6) or mold killer (T3) to an aflatoxin – containing diet significantly improved the adverse effects of aflatoxin on haematological and biochemical traits. However, results of the current study clearly show that liquorice extract, especially at the level of 450 mg / kg effectively diminished the detrimental effects of aflatoxicosis on the general physiological status of broiler chickens.