Objective - The objective of the present work was to study the antipyretic activity of plant Capparis zeylanica Linn. belonging to family Capparaceae, known as “Karambha” in Sanskrit & “Asadhua” in Oriya. Materials & Methods - The Methanolic extract was taken for the study and evaluated for antipyretic activity using Brewer’s yeast induced pyrexia in Wister strain albino rats. The methanolic extract at a dose of 100mg/kg & 200mg/kg were evaluated for antipyretic activity. Result - The extract of C. zeylanica plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. Conclusion - The Methanolic extract of Capparis. zeylanica Linn. plant have significant antipyretic activity when compared with the standard drug. So. It can be recommended for further studies.