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ANTICONVULSANT ACTIVITY OF GLYCYRRHIZIC ACID IN MICE

Keywords: Convulsions , PTZ , Isoniazid , Diazepam , Glycyrrhizic acid , ammonium salt

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Abstract:

This investigation has been carried out to evaluate Glycyrrhizic acid, ammonium salt for its anticonvulsant effect. It is chemically pentacyclic triterpenoid saponin glycoside belonging to -amyrin series. It’s ammonium salt is water soluble above pH 4.5.This salt enhances the activity of Glutamate transaminase. Literature survey has shown that no work has been carried out to evaluate anticonvulsant action of Glycyrrhizic acid and also shown that the toxicological studies of monoammonium salt of Glycyrrhizic acid has no side effects when administered in mice and rats .The convulsions were evoked by Pentylenetetrazole (80mg/Kgs.c) and Isoniazid (300mg/Kg s.c). Systemic administration (i.p) of 100, 200, 300, 400 mg/Kg dose of Glycyrrhizic acid was able to delay the onset of convulsions and death in dose dependent manner. The results were found to be significant with p-Values for Pentylenetetrazole and Isoniazid induced convulsions as 0.001 and 0.002 respectively as compared to vehicle treated group and thus glycyrrhizic acid possess anticonvulsant action.

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