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Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome

DOI: 10.1186/1477-7827-10-36

Keywords: Luteinizing hormone, Luteinizing hormone receptor, Polycystic ovary syndrome, Gene polymorphism

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Abstract:

315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls (p=0.001). Within PCOS group, carriers of LH 1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with LHR rs61996318 polymorphisms. A new LHR single nucleotide polymorphism (SNP) was found without clear association with PCOS.Results suggested LH G1052A mutation might influence PCOS susceptibility and phenotypes.

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