All Title Author
Keywords Abstract

Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome

DOI: 10.1186/1477-7827-10-36

Keywords: Luteinizing hormone, Luteinizing hormone receptor, Polycystic ovary syndrome, Gene polymorphism

Full-Text   Cite this paper   Add to My Lib


315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls (p=0.001). Within PCOS group, carriers of LH 1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with LHR rs61996318 polymorphisms. A new LHR single nucleotide polymorphism (SNP) was found without clear association with PCOS.Results suggested LH G1052A mutation might influence PCOS susceptibility and phenotypes.


comments powered by Disqus