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Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto?) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe

DOI: 10.1186/1756-3305-5-66

Keywords: Ctenocephalides felis, Ctenocephalides canis, Archaeopsylla erinacei, Pulex irritans, Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus, Fleas, Ticks, Efficacy, Safety, Imidacloprid, Flumethrin, Collar, Field

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Abstract:

232 (IVP) and 81 (CP) cats and 271(IVP) and 129 (CP) dogs were treated with either product according to label claims and formed the safety population. Flea and tick counts were conducted in monthly intervals for up to 8 months in the efficacy subpopulation consisting of 118 (IVP) + 47 (CP) cats and 197 (IVP) + 94 (CP) dogs. Efficacy was calculated as reduction of infestation rate within the same treatment group and statistically compared between the two treatment groups.Preventive efficacy against fleas in cats/dogs varied in the IVP group between 97.4%/94.1% and 100%/100% (overall mean: 98.3%/96.7%) throughout the 8 month period and in the CP group between 57.1%/28.2% and 96.1%/67.8% (overall mean: 79.3%/57.9%). Preventive efficacy against ticks in cats/dogs varied in the IVP group between 94.0%/91.2% and 100%/100% (overall mean: 98.4%/94.7%) throughout the 8 month period and in the CP group between 90.7%/79.9% and 100%/88.0% (overall mean: 96.9%/85.6%). The IVP group was statistically non-inferior to the CP group, and on various assessment days, statistical superiority was proven for flea and tick count reduction in dogs and cats. Both treatments proved to be safe in dogs and cats with mainly minor local observations at the application site. There was moreover, no incidence of any mechanical problem with the collar in dogs and cats during the entire study period.The imidacloprid/flumethrin collar proved to reduce tick counts by at least 90% and flea counts by at least 95% for a period of at least 7-8 months in cats and dogs under field conditions. Therefore, it can be used as sustainable long-term preventative, covering the whole flea and tick season.Fleas and ticks are common ectoparasites in dogs and cats and are present in many areas of the world, in differing intensity depending on the climatic conditions. Fleas are present in all areas of Europe, with Ctenocephalides felis being the most frequent flea species on our companion animals followed by Ctenocephalid

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