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Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob

DOI: 10.1186/1743-7075-6-27

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Abstract:

For this purpose, 200 days old male 6 lean and 6 obese rats of both strains were taken. Fatty acid composition was analyzed in plasma, various tissues such as liver, white adipose tissues (retroperitoneal, epididymal, omental, and subcutaneous) and brown adipose tissue.Fatty acid composition data showed significant increase in palmitoleic (16:1) and oleic (18:1) acid levels, which were reflected in increased desaturation index (16:1/16:0 and 18:1/18:0) in plasma and all the tissues of obese rats of both strains, when compared with their respective age and sex-matched lean rats. Further, we found a strong positive correlation between desaturation index, BMI and AI in plasma and most of the tissues analyzed.So far, plasma Δ9 desaturation index has been well correlated with hypertriglyceridemia and we, by employing two models of obesity namely, WNIN/Ob and WNIN/GR-Ob, have shown Δ9 desaturation index of plasma correlated with physical markers of obesity such as BMI and AI. In conclusion, Δ9 desaturation index may serve as a potential sensitive biochemical marker to assess the degree of obesity and impact of therapeutic/nutritional interventions to combat obesity, along with other indicators.Obesity, arising out of modern lifestyle has attained the status of "globesity" and affecting the health of millions of people with various socio-economic consequences. Obesity, a condition caused by imbalanced energy homeostasis, manifests itself as excessive fat deposition and often associated with several morbidities, such as type 2 diabetes, hypertension, coronary heart disease, and certain types of cancers, respiratory complications and osteoarthrites [1]. Microsomal stearoyl-CoA desaturase1 (SCD1) is the rate limiting enzyme involved in the biosynthesis of monounsaturated fatty acids (MUFA); palmitoleoyl and oleoyl-CoAs from their respective substrates palmitoyl and stearoyl-CoAs by Δ9-cis desaturation. These MUFAs are major substrates for the synthesis of various lipids such

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