The aim of this study was to investigate the effect of organic and inorganic fertilizers on growth and yield of five upland black glutinous rice varieties and soil property. Two experiments were conducted at Khon Kaen University, Thailand during the rainy seasons of 2007 and 2008. Experiments were laid out in a split-plot design with four replications. Four fertilizer treatments (control, farmyard manure (FYM) or cattle manure at a rate of 10 t ha-1, NPK at the rate of 50-22-42 kg N-P-K ha-1, the combination of the FYM and NPK were randomized in the main plots and five black glutinous rice varieties (KKU-GL-BL-05-002, KKU-GL-BL-05-003, KKU-GL-BL-05-004, KKU-GL-BL-05-009 and KKU-GL-BL-05-010) were randomized in the sub plots. Soil samples before fertilizer application and after harvesting were analyzed to determine chemical and physical properties. Leaf Area Index (LAI) and shoot dry matter were recorded at 40 days after planting, panicle initiation and flowering stages. Number of tillers and panicles per hill and grains per panicle, thousand grain weight, number of filled and unfilled grains and grain yield were recorded at harvest time. The results from both years indicated that using the combination of FYM and inorganic fertilizers increased shoot dry matter, LAI, tiller and panicle number per hill, grain number per panicle and grain yield. It was recorded that application of FYM together with inorganic fertilizers significantly increased soil organic matter, CEC, N, P and K. Comparing among the five varieties, KKU-GL-BL-05-002 had highest grain number per panicle and grain yield in both years.