Nowadays, there has been an increased interest in various natural plants as a source of biological active compounds including polyphenols. Important sources of these phytochemicals are less known pseudocereals such as amaranth and buckwheat. The objective of this study was determination of antimycotic and antifungal effects of mentioned pseudocereals. Antimicrobial screening against selected three yeast strains and four strains of fungi was carried out on DMSO buckwheat and amaranth extracts prepared by alkali hydrolyses. Results suggested variation in the antimicrobial properties of tested extracts. The studied extracts suppressed growth of Aspergillus flavus, Fusarium culmorum and Alternaria alternata. No inhibitory effect was observed against Rhizopus oryzae and tested yeast.