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HLA-A24: factor de riesgo en retinopatía diabética proliferante

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HLA-A24: factor de riesgo en retinopatía diabética proliferante HLA-A24: risk factor in proliferante diabetic retinopathy

Keywords: Diabetes insulindependiente , retinopatía diabética proliferante , HLA , HLA-A24 , factor de riesgo , Insulin-dependent diabetes , proliferative diabetic retinopathy , HLA , HLA-A24 , risk factor

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Objetivo: La retinopatía diabética proliferante (RDP) se caracteriza por pérdida de la visión en la población joven. Está bien establecido que el antígeno leucocitario humano (HLA)-A24 es un factor de riesgo para la pérdida total de las células del páncreas. Nuestro objetivo es estudiar la asociación del HLA-A24 con la RDP. Material y método: Se estudió un grupo de pacientes con RDP (n= 95) y un grupo control (n= 60). A todos se les determinó el HLA-A24 mediante técnicas hibridación molecular. Resultados: El grupo control mostró menos frecuencia de HLA-A24 que el grupo con RDP (p= 0,043). El HLA-A24 se asoció a retinopatía diabética proliferante (OR = 5,4; 95% CI= 3,2-7,6; p< 0,001). Conclusiones: El HLA-A24 no es un factor de protección para la retinopatía diabética proliferante, es un factor de riesgo para desarrollarla. Objective: Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)-A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR. Materials and methods: We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques. Results: The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001). Conclusions: HLA-A24 is not a protective factor for PDR, but is a risk factor of its development.

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