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Influence of liver cancer on lipid and lipoprotein metabolism

DOI: 10.1186/1476-511x-5-4

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Plasma lipid profiles could be changed under HCC. In majority of the reports in HCC, plasma levels of triglycerides (TG), cholesterol, free fatty acids (FFA), HDL, low-density lipoproteins (LDL), lipoprotein (a) (Lp(a)), apolipoprotein AI (apoAI) and apoB were slight to significantly decreased, however, in some cases plasma levels of TG and Lp(a) might be increased. It has been suggested that analysis of plasma levels of lipids, lipoproteins and apolipoproteins in the patients suffered from HCC reflects on the hepatic cellular impairment status. Studies revealed that alterations seen in the plasma levels of lipids, lipoproteins and apolipoproteins reflecting patients' pathologic conditions. Decreased serum levels of cholesterol and apoAI may indicate a poor prognosis.Human leukaemic cells and certain tumor tissues have a higher receptor-mediated uptake of HDL and LDL than the corresponding normal cells or tissues. LDL and HDL have therefore been proposed as a carrier for the water-insoluble anti-cancer agents.Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver [1,2], which depends on the integrity of cellular functions of liver [2,3]. Under normal physiological conditions, liver ensures homeostasis of lipid and lipoprotein metabolism [4]. Hepatic cellular damage and HCC impairs these processes, leading to alterations in plasma lipid and lipoprotein patterns. Mortality due to liver cancer is the fifth common malignant tumor worldwide [5], and it is closely related to the infections of hepatitis B virus (HBV) [6-8] and hepatitis C virus (HCV) [9]. HBV proteins, such as the hepatitis B X protein (HBx) that is large hepatitis B surface protein could regulate transcription of many candidate genes for liver carcinogenesis [10,11]. As HBV and HCV infections are quite common in China and in other Southeast Asian countries [12-14], the mortality of HCC is 20,4/100,000 in


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