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The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance

DOI: 10.1186/1479-5876-9-95

Keywords: metastasis suppressor-1, MTSS1, MIM, oesophageal squamous cell carcinoma, metastasis

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Abstract:

In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells.Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness.MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy.Tumour metastasis is the most significant contributor to the mortality of patients with cancers. Metastasis of cancer cells proceeds via a long series of sequential, interrelated steps modulated largely by activators and suppressors of metastasis. Metastasis suppressor genes are defined by their ability to inhibit metastasis at any step of the metastatic cascade. To date, only a limited number of metastasis suppressor genes, including NM23, KAI1, KiSS1, MKK4, BRMS1, RHOGDI2, CRSP3 and VDUP1, have been identified [1]. These metastasis suppressor genes inhibit metastasis of a cancer cell line in vivo without blocking its tumourigenicity.MTSS1 (metastasis suppressor-1), also known as MIM (Missing-In-Metastasis), MIM-B, BEG4 (Basal cell carcinoma-enriched gene 4) or KIAA0429, was first identified as a potential metastasis suppressor gene missing in metastatic bladder carcinoma cell lines [2] and subsequently investigated in some types

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