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Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma

DOI: 10.1186/1756-9966-29-146

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Abstract:

We catalogued all published interactions between HBV and human proteins, identifying 250 descriptions of HBV and human protein interactions and 146 unique human proteins that interact with HBV proteins by text mining.Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HBV are made up of core proteins that are interconnected with many pathways. A global analysis based on functional annotation highlighted the enrichment of cellular pathways targeted by HBV.By connecting the cellular proteins targeted by HBV, we have constructed a central network of proteins associated with hepatocellular carcinoma, which might be to regard as the basis of a detailed map for tracking new cellular interactions, and guiding future investigations.Hepatitis B virus is one of the most common infectious diseases in the world, and 43 years after its discovery, it still has a great impact on health, particularly in developing countries. More than 350 million people worldwide are known to be chronic carriers of HBV, and each year 15 million people die of hepatitis [1].The HBV viral genome is a relaxed-circular, partially duplex DNA of 3,200 base pairs. It has five genes encoding polymerase, pre-S1/pre-S2/S, X protein, precore/core protein, and the ID2828293 gene which is not well understood without an official gene symbol or description[2]. These proteins can also trans-activate other cellular genes, which may play a role in hepatocarcinogenesis [3].Hepatocellular carcinoma is one of the most common fatal cancers worldwide [4]. HBV is strongly associated with HCC by its presence in the tumor cell and by the striking role of persistent HBV infection as a risk factor for the development of HCC[2]. The incidence of HCC in many countries is increasing in parallel to an increase in chronic HBV infection[1]. It is generally shown that vaccination significantly decreases the incidence of HCC. Moreover, preventing the most severe HBV diseas

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