All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99

ViewsDownloads

Relative Articles

从改善“脂毒性”看六味地黄丸对自发性糖尿病OLETF大鼠肝脏的保护
Effects of Liuwei Dihuang Pills on lipid metabolism and the liver structure in spontaneously diabetic OLETF rats

Identification of Chemical and Metabolic Components of Liuwei Dihuang Pills by Ultra Fast Liquid Chromatography-Electrospray-Ion Trap-Time of Flight Mass Spectrometry
UFLC-ESI-IT-TOF鉴定六味地黄丸中的化学成分和代谢成分

Clinical Study Progress on Liuwei Dihuang Pill
六味地黄丸临床研究进展

History Progress of Pharmacology of Traditional Chinese Medical Formulae about Liuwei Dihuang Pill and its clinical application in ancient times
六味地黄丸方剂学历史沿革及古代临床应用概况

Comments on Quality Administration System of Liuwei Dihuang Pill in Tongrentang
同仁堂六味地黄丸质量保障体系评述

Use of Ultrafiltration Technology in the Purification of Polysaccharide from Liuwei Dihuang Decoction
超滤技术在六味地黄软胶囊多糖精制工艺中的应用

Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats

Liuwei Dihuang (LWDH), a Traditional Chinese Medicinal Formula, Protects against β-Amyloid Toxicity in Transgenic Caenorhabditis elegans

Assessing the microcirculatory response following oral administration of Liuwei Dihuang formula by spectral analysis of skin-surface laser Doppler signals

Effects of Chinese herbal medicine Liuwei Dihuang Pill and its main monomer catalpol on transforming growth factor-β1/Smad pathway in HK-2 cells

More...

Effects of Liuwei Dihuang Pills on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats

Keywords: diabetes mellitus type 2 , apoptosis , gene , bcl-2 , gene Bax , Liuwei Dihuang Decoction , rats , OLETF

Full-Text   Cite this paper   Add to My Lib

Abstract:

Objective: To investigate the effects of Liuwei Dihuang Pills (LWDHP) on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats. Methods: Forty male OLETF rats were randomly divided into LWDHP-treated group and untreated group. Another ten male LETO rats were included in normal control group. OLETF rats in the LWDHP-treated group were given LWDHP (2.4 g·kg-1·d-1) orally since the age of 8 weeks and the rats in the other two groups were given distilled water orally. Body weights of rats were recorded weekly and blood glucose concentration was determined by oral glucose tolerance test (OGTT). Pancreas weights were recorded after rats were killed and the expression levels of bcl-2 mRNA and Bax mRNA were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Results: In the LWDHP-treated group, the expression of bcl-2 mRNA in the pancreas of rats at the age of 40 weeks (1.25±0.07) was much higher than that in the untreated group (1.01±0.16), P<0.01. Bax mRNA level in the LWDHP-treated group (0.57±0.11) was obviously lower than that in the untreated group (1.18±0.28), P<0.01. There was no significant difference of pancreas-to-body weight ratios between the LWDHP-treated group and the untreated group. The ability of glucose tolerance was improved in the LWDHP-treated group. Conclusion: LWDHP can up-regulate the expression of bcl-2 and down-regulate the expression of Bax at transcription level, which maybe contribute to the anti-apoptosis effects of LWDHP.

Full-Text

comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

微信:OALib Journal