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Genetic predictors of idiopathic sick sinus syndrome

Keywords: idiopathic sinus syndrome , genetic determinism , myosin heavy chains (MYH6) gene , SCN5A , HCN4 , konneksin-40 , ADRA2B gene , endothelial NO-synthase gene

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Published data demonstrating genetic determination of sick sinus syndrome is presented. The definition of this pathology is presented; the main symptoms are described, as well as genes that influence the development of idiopathic sick sinus syndrome, their polymorphisms and role in disorders of the cardiovascular system.


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