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Modulation of oxidative stress and microinflammatory status by colloids in refractory dialytic hypotension

DOI: 10.1186/1471-2369-12-58

Keywords: dialytic hypotension, 4% gelatin, 20% hyperoncotic albumin, microinflammatory status, oxidative stress

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Abstract:

We postulated that frequent hypotensive episodes may lead to a noxious inflammatory response mediated by oxidative stress induced by ischemia-reperfusion. The aim of this study was therefore to analyze the effect of 20% albumin and 4% gelatin infusions on oxidative stress and microinflammatory status in hypotension-prone patients unresponsive to usual preventive measures.Prospective cross-over study (lasting 20 weeks) of routine infusion of 200 ml of 20% albumin versus 200 ml of 4% gelatin in 10 patients with refractory intradialytic hypotension. We analyzed the effect of 20% albumin and 4% gelatin on microinflammatory status, oxidative stress, serum nitrite and nitrate levels by analysis of variance.A significant decrease in serum ceruloplasmin and serum C3 was observed during the albumin period (p < 0.05, repeated measure ANOVA). A significant decrease in serum hydrogen peroxide was seen during albumin and gelatin administration (p < 0.01, repeated measure ANOVA) and a very large decrease in serum lipid peroxides was observed during the albumin period only (p < 0.01, Friedman test). Serum lactoferrin, serum proinflammatory cytokines and serum nitrite and nitrate levels remained stable during the different periods of this pilot trial.We conclude that the improvement in microinflammatory status observed during colloid infusion in hypotension-prone dialysis patients may be related to a decrease in ischemia-reperfusion of noble organs, together with a specific reduction in oxidative stress by albumin.ISRCTN 20957055Intradialytic hypotension is the most common complication of hemodialysis, affecting up to 33% of patients. It interferes with patients' well being and prevents adequate dialysis and fluid removal [1-3]. Intradialytic hypotension has a negative impact on health-related quality of life and reduces patients' life expectancy, favoring underdialysis and increasing the risk of ischemia or infarction of noble organs such as the heart, brain and bowel [2-4].Recent

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