Pain relieving drugs are one of the most commonly useddrugs worldwide either through prescription or as overthe counter medication. Non-steroidal anti-inflammatorydrugs usually abbreviated as NSAIDs, are the drugs withanalgesic, antipyretic and, in higher doses, with antiinflammatoryeffects. NSAIDs inhibit cyclooxygenase(COX) 1 and 2. So, most of the side effects develop as aresult of cyclooxygenase inhibitory activity. CertainNSAIDs, for example, rofecoxib and nimesulide havebeen banned because of their adverse effects.Lornoxicam (chlortenoxicam) is a strong analgesic andanti-inflammatory NSAID of the oxicam class with bettertolerability profile when compared to other NSAIDs. Itsanalgesic activity is comparable to that of opioids. It hasbeen shown to be effective in the treatment of postoperative pain and rheumatoid arthritis (RA). The presentreview provides an overview of lornoxicam.