Study of palmo-plantar keratoderma in eighty-two cases showed that twenty different diseases, both hereditary and acquired were responsible for palmoplantar keratoderma. Maximum number of cases were of hereditary variety of palmoplantar keratoderma (Unna-Thost syndrome) (28.05%). Whereas psoriasis was the leading cause among the acquired conditions (17.07%). Two histopathological types of Unna-Thost syndrome and their correlation with clinical features are reported.
